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TAS2R38 - taste receptor, type 2, member 38
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Entrez Gene Name: taste receptor, type 2, member 38
Entrez GeneID: Human(5726)
, Mouse(387513), Rat(500091)
, Mouse(387513), Rat(500091) Synonyms: mt2r31, PTC, T2R138, T2R38, T2R61, Tas2r138, TAS2R38
Gene Summary
- Human (5726): This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
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Biological Process
detection of chemical stimulus involved in sensory perception of bitter taste, G-protein coupled receptor protein signaling pathway, response to stimulus, sensory perception of taste, signal transduction
Literature References
- 18003842Behrens M, Foerster S, Staehler F, Raguse JD, Meyerhof W. Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells.J Neurosci 2007 Nov 14;27(46):12630-40
- 16720576Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W. Members of RTP and REEP Gene Families Influence Functional Bitter Taste Receptor Expression.J Biol Chem 2006 Jul 21;281(29):20650-9
Molecular Functions
G-protein coupled receptor activity, receptor activity, signal transducer activity, taste receptor activity