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DRD3 - dopamine receptor D3
Entrez Gene Name: dopamine receptor D3
Entrez GeneID: Human(1814)
, Mouse(13490), Rat(29238)
, Mouse(13490), Rat(29238) Synonyms: D3 receptor, D3DR, D3R, Dopamine d3 receptor, DRD3, ETM1, FET1, MGC149204, MGC149205
Gene Summary
- Human (1814): This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
- Rat (29238): may be involved in facilitating the effects of antipsychotic drugs and drug treatments for Parkinson's disease [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Binds:
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Biological Process
acid secretion, activation of adenylate cyclase activity by dopamine receptor signaling pathway, arachidonic acid secretion, behavioral response to cocaine, cellular calcium ion homeostasis, circadian regulation of gene expression, dopamine metabolic process, dopamine receptor signaling pathway, G-protein coupled receptor internalization, G-protein coupled receptor protein signaling pathway, inhibition of adenylate cyclase activity by dopamine receptor signaling pathway, learning, learning or memory, locomotory behavior, musculoskeletal movement, spinal reflex action, negative regulation of adenylate cyclase activity, negative regulation of blood pressure, negative regulation of dopamine receptor signaling pathway, negative regulation of oligodendrocyte differentiation, negative regulation of protein kinase B signaling cascade, negative regulation of protein secretion, negative regulation of sodium:hydrogen antiporter activity, negative regulation of transcription from RNA polymerase II promoter, positive regulation of cell proliferation, positive regulation of dopamine receptor signaling pathway, positive regulation of mitosis, positive regulation of renal sodium excretion, positive regulation of transcription from RNA polymerase II promoter, prepulse inhibition, regulation of blood volume by renin-angiotensin, regulation of cAMP metabolic process, regulation of circadian sleep/wake cycle, sleep, regulation of dopamine secretion, regulation of dopamine uptake, regulation of lipid metabolic process, regulation of locomotion, regulation of multicellular organism growth, response to amphetamine, response to cocaine, response to drug, response to ethanol, response to histamine, response to morphine, signal transduction, social behavior, synaptic transmission, synaptic transmission, dopaminergic, visual learning
Cellular Components
apical part of cell, cell projection, endocytic vesicle, integral to membrane, integral to plasma membrane, membrane, membrane fraction, plasma membrane
Literature References
- 19520868Villar VA, Jones JE, Armando I, Palmes-Saloma C, Yu P, Pascua AM, Keever L, Arnaldo FB, Wang Z, Luo Y, Felder RA, Jose PA. G Protein-coupled Receptor Kinase 4 (GRK4) Regulates the Phosphorylation and Function of the Dopamine D3 Receptor.J Biol Chem 2009 Aug 07;284(32):21425-34
- 18424554Fiorentini C, Busi C, Gorruso E, Gotti C, Spano P, Missale C. Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization.Mol Pharmacol 2008 Jul 01;74(1):59-69
- 18380665Zhan L, Liu B, Jose-Lafuente M, Chibalina MV, Grierson A, Maclean A, Nasir J. ALG-2 interacting protein AIP1: a novel link between D1 and D3 signalling.Eur J Neurosci 2008 Apr 01;27(7):1626-33
Molecular Functions
dopamine binding, dopamine D3 receptor activity, dopamine receptor activity, dopamine receptor activity, coupled via Gi/Go, drug binding, G-protein coupled receptor activity, protein binding, protein domain specific binding, receptor activity, signal transducer activity
Protein Domains
7 transmembrane receptor (rhodopsin family), cytoplasmic domain, cytoplasmic loop, dopamine D2 receptor-like receptor, dopamine D3 receptor, dopamine receptor, drug binding, G-protein coupled receptor, intracellular domain, intracellular loop, protein binding, protein domain specific binding, third intracellular loop
Subcellular Locations
apical compartment, apical membrane, brush border, cellular membrane, cellular protrusions, Cytoplasm, cytosol, endocytotic vesicle, membrane fraction, microsomal fraction, outer membranes, pedicels, perikaryon, Plasma Membrane, vesicles