ACTA2 - actin, alpha 2, smooth muscle, aorta
Entrez Gene Name: actin, alpha 2, smooth muscle, aorta
Entrez GeneID: Human(59)
, Rat(81633)
, Rat(81633) Synonyms: 0610041G09RIK, a-SMA, AAT6, ACTA2, ACTSA, Actvs, ALPHA ACTIN VSM, ALPHA SMA, ALPHA SMOOTH MUSCLE ACTIN, ALPHA-ACTIN 2, FLJ45296, MGC127800, RGD: 621676, Similar to vascular alpha actin, Sm alpha actin, SMalphaA, SMOOTH MUSCLE ALPHA ACTIN
Gene Summary
- Human (59): The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
- Rat (81633): contractile protein; required for extracellular matrix remodeling [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actomyosin structure organization, apoptosis, cardiac muscle tissue morphogenesis, cardiac myofibril assembly, muscle contraction, muscle thin filament assembly, regulation of blood pressure, vascular smooth muscle contraction
Cellular Components
actin cytoskeleton, cytoplasm, cytoskeleton, I band, smooth muscle contractile fiber
Literature References
- 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 14592989Stuven T, Hartmann E, Gorlich D. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.EMBO J 2003 11 3;22(21):5928-40 View 2819 categorized literature findings and their references in IPA
- Clathrin-mediated Endocytosis Signaling
- Tight Junction Signaling
- Mechanisms of Viral Exit from Host Cells
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Cellular Effects of Sildenafil (Viagra)
- NRF2-mediated Oxidative Stress Response
- VEGF Signaling
- ILK Signaling
- Virus Entry via Endocytic Pathways
- Agrin Interactions at Neuromuscular Junction
- Calcium Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- FAK Signaling
- Integrin Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Caveolar-mediated Endocytosis Signaling
- Regulation of Actin-based Motility by Rho
- Actin Cytoskeleton Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Leukocyte Extravasation Signaling
