MTMR3 - myotubularin related protein 3
Entrez Gene Name: myotubularin related protein 3
Entrez GeneID: Human(8897)
, Mouse(74302), Rat(305482)
, Mouse(74302), Rat(305482) Synonyms: 1700092A20Rik, AI255150, AW557713, FLJ32333, FYVE ZINC FINGER PTP, FYVE-DSP1, KIAA0371, MGC78036, mKIAA0371, MTMR3, ZFYVE10
Gene Summary
- Human (8897): This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 16787938Lorenzo O, Urbé S, Clague MJ. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.J Cell Sci 2006 Jul 15;119(Pt 14):2953-9
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78 View 25 categorized literature findings and their references in IPA
Molecular Functions
hydrolase activity, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, zinc ion binding
Protein Domains
FYVE domain, phosphatase, protein serine/threonine phosphatase, protein-tyrosine-phoshatase, zinc ion binding
