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HHAT - hedgehog acyltransferase
Entrez Gene Name: hedgehog acyltransferase
Entrez GeneID: Human(55733)
, Mouse(226861), Rat(289344)
, Mouse(226861), Rat(289344) Synonyms: 2810432O22RIK, AI462858, FLJ10724, FLJ34867, HHAT, MART2, MGC11697, RGD1311746, SKI1, Skn
Gene Summary
- Human (55733): 'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
metabolic process, multicellular organismal development, protein palmitoylation, smoothened signaling pathway
Cellular Components
endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane
Literature References
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 16397407Patil MA, Zhang J, Ho C, Cheung ST, Fan ST, Chen X. Hedgehog signaling in human hepatocellular carcinoma.Cancer Biol Ther 2006 Jan 01;5(1):111-7
- 16258256Katoh Y, Katoh M. Hedgehog signaling pathway and gastric cancer.Cancer Biol Ther 2005 Oct 01;4(10):1050-4
Molecular Functions
GTP binding, nucleotide binding, palmitoyltransferase activity, transferase activity, transferase activity, transferring acyl groups