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MYLK3 - myosin light chain kinase 3
Entrez Gene Name: myosin light chain kinase 3
Entrez GeneID: Human(91807)
, Mouse(213435), Rat(291926)
, Mouse(213435), Rat(291926) Synonyms: caMLCK, D830007F02RIK, LOC633594, MGC126319, MGC126320, MGC169607, MLCK, MLCK2, MYLK3, RGD1305801
Gene Summary
- Human (91807): Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cardiac myofibril assembly, cellular response to interleukin-1, phosphorylation, positive regulation of sarcomere organization, protein phosphorylation, regulation of vascular permeability involved in acute inflammatory response, sarcomere organization, sarcomerogenesis
Literature References
- 20404178Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function.Proc Natl Acad Sci U S A 2010 May 04;107(18):8237-41
- 18390750Al-Sadi R, Ye D, Dokladny K, Ma TY. Mechanism of IL-1{beta}-Induced Increase in Intestinal Epithelial Tight Junction Permeability.J Immunol 2008 Apr 15;180(8):5653-61
- 2956925Edelman AM, Blumenthal DK, Krebs EG. Protein serine/threonine kinases.Annu Rev Biochem 1987;56:567-613
Molecular Functions
ATP binding, calmodulin-dependent protein kinase activity, kinase activity, myosin light chain kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups
Protein Domains
amphipathic helix, calmodulin regulated protein kinase, kinase, myosin-light-chain kinase, Protein kinase (unclassified specificity), Protein kinase domain, Protein Kinases, catalytic domain, protein serine/threonine kinase, Protein tyrosine kinase, Serine/Threonine protein kinases, catalytic domain, Tyrosine kinase, catalytic domain