HIST4H4 (includes EG:121504) - histone cluster 4, H4
Entrez Gene Name: histone cluster 4, H4
Entrez GeneID: Human(121504)
, Mouse(319159)
, Mouse(319159) Synonyms: B130044J01Rik, H4, H4/p, HIST1H4A, Hist1h4j, Hist1h4k, HIST4H4 (includes EG:121504), HST4H4, MGC24116
Gene Summary
- Human (121504): Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Literature References
- 11163245Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D. Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein.Cell 2001 Jan 12;104(1):119-30
- 15765097Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Perez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.Nat Genet 2005 04 1;37(4):391-400
- 18474616Sims JK, Rice JC. PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation.Mol Cell Biol 2008 Jul 01;28(14):4459-68 View 50 categorized literature findings and their references in IPA
