-
Product Directory
Custom Product
-
Services Offered
Custom Capabilities
-
SPPL2A - signal peptide peptidase-like 2A
Canonical
Pathway
Entrez Gene Name: signal peptide peptidase-like 2A
Entrez GeneID: Human(84888)
, Mouse(66552), Rat(311401)
, Mouse(66552), Rat(311401) Synonyms: 2010106G01RIK, C130089K23Rik, IMP3, PSL2, RGD1563001, RP23-130L11.5, SPPL2A
Gene Summary
- Human (84888): This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with a protease associated (PA) domain. This protein plays a role in innate and adaptive immunity. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Jul 2008]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
|
Literature References
- 15385547Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B. Consensus analysis of signal Peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.J Biol Chem 2004 Dec 03;279(49):50790-8
- 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 10 20;437(7062):1173-8
- 17965014Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C. Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.J Biol Chem 2008 Jan 18;283(3):1644-52