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HDAC11 - histone deacetylase 11

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List

Gene
Details

Interaction
Network

Canonical
Pathway

Literature

Clinical Trial

Disease

Compound

Expression

Regulation

SNP

Entrez Gene Name: histone deacetylase 11
Entrez GeneID: Human(79885), Mouse(232232), Rat(297453)
Synonyms: FLJ22237, HD11, HDAC11, MGC27683

Gene Summary

  • Human (79885): This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • Histone
  • Histone h3
  • reporter gene
View all 74 in IPA
Regulated by:
  • trichostatin A
  • trapoxin
  • butyric acid
View all 64 in IPA
Binds:
  • Mef2
  • NCOR2
  • RB1
View all 59 in IPA
Role in cell:
  • expression in
  • apoptosis
  • cell cycle progression
View all 26 in IPA
Disease:
  • adult solid tumor
  • lymphoid cancer
  • myelodysplastic syndrome
View all 57 in IPA

Biological Process

chromatin modification, histone deacetylation, oligodendrocyte development, regulation of transcription, DNA-dependent, transcription, DNA-dependent

Cellular Components

cytoplasm, histone deacetylase complex, nucleus, plasma membrane

Literature References

  • 15822187Drummond DC, Noble CO, Kirpotin DB, Guo Z, Scott GK, Benz CC. Clinical development of histone deacetylase inhibitors as anticancer agents.Annu Rev Pharmacol Toxicol 2005 Jan 01;45:495-528
  • 12202037Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, Olson EN. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy.Cell 2002 Aug 23;110(4):479-88
  • 21239696Buglio D, Khaskhely NM, Voo KS, Martinez-Valdez H, Liu YJ, Younes A. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma.Blood 2011 Mar 10;117(10):2910-7
View 732 categorized literature findings and their references in IPA

Molecular Functions

histone deacetylase activity, histone deacetylase activity (H3-K14 specific), histone deacetylase activity (H3-K16 specific), histone deacetylase activity (H3-K9 specific), hydrolase activity, NAD-dependent histone deacetylase activity (H3-K14 specific), NAD-dependent histone deacetylase activity (H3-K9 specific), NAD-dependent histone deacetylase activity (H4-K16 specific), protein binding, transcription factor binding

Pathways

Protein Domains

histone deacetylase, Histone deacetylase domain, protein binding, transcription factor binding, transcription regulator

Subcellular Locations

Cytoplasm, Nucleus, Plasma Membrane

IPA Extras