YFG Logo
HS3ST2 - heparan sulfate (glucosamine) 3-O-sulfotransferase 2

Product
List

Gene
Details

Interaction
Network

Canonical
Pathway

Literature

Clinical Trial

Disease

Compound

Expression

Regulation

SNP

Entrez Gene Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Entrez GeneID: Human(9956), Mouse(195646), Rat(293451)
Synonyms: 3-OST2, 30ST2, 6430516N12RIK, A830061E14, A830061E14Rik, AW491345, h3-OST-2, HS3ST2

Gene Summary

  • Human (9956): Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq]
  • Rat (293451): catalyzes the transfer of sulfate groups onto the 3-OH site of glucosamine groups in heparan sulfate proteoglycans [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • steroid
  • pregnenolone sulfate
  • pregnenolone
View all 8 in IPA
Regulated by:
  • CAR ligand-CAR-Retinoic acid-RXRα
  • decitabine
  • bucladesine
View all 13 in IPA
Binds:
  • miR-218/miR-218a
  • miR-194
  • miR-889
View all 17 in IPA
Role in cell:
  • No Data Available
Disease:
  • rheumatoid arthritis
  • coronary artery disease
View all 3 in IPA

Biological Process

circadian rhythm, metabolic process

Cellular Components

Golgi apparatus, Golgi membrane, integral to membrane, membrane

Literature References

  • 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
  • 12527896Miyamoto K, Asada K, Fukutomi T, Okochi E, Yagi Y, Hasegawa T, Asahara T, Sugimura T, Ushijima T. Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O- sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers.Oncogene 2003 Jan 16;22(2):274-80
  • 19103603Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC. Night/Day Changes in Pineal Expression of >600 Genes: CENTRAL ROLE OF ADRENERGIC/cAMP SIGNALING.J Biol Chem 2009 Mar 20;284(12):7606-22
View 85 categorized literature findings and their references in IPA

Molecular Functions

heparan sulfate -glucosamine 3-sulfotransferase 1 activity, heparan sulfate -glucosamine 3-sulfotransferase 2 activity, sulfotransferase activity, transferase activity

Pathways

Protein Domains

heparan sulfate -glucosamine 3-sulfotransferase 1, heparan sulfate -glucosamine 3-sulfotransferase 2, enzyme, Sulfotransferase domain

Subcellular Locations

Cytoplasm, detergent resistant lipid raft fraction, Golgi membranes, pH resistant lipid raft fraction

IPA Extras