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KDM5C - lysine (K)-specific demethylase 5C
Canonical
Pathway
Entrez Gene Name: lysine (K)-specific demethylase 5C
Entrez GeneID: Human(8242)
, Mouse(20591)
, Mouse(20591) Synonyms: DXS1272E, JARID1C, KDM5C, mKIAA0234, MRXJ, MRXSJ, SMCX, XE169
Gene Summary
- Human (8242): This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
chromatin modification, oxidation-reduction process, regulation of transcription, DNA-dependent, transcription, DNA-dependent
Literature References
- 17468742Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, Shimizu F, Li J, Rao A, Shi Y. The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.Nature 2007 05 31;447(7144):601-5
- 18078810Kim TD, Shin S, Janknecht R. Repression of Smad3 activity by histone demethylase SMCX/JARID1C.Biochem Biophys Res Commun 2008 Feb 08;366(2):563-7
- 20211142Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y. An atlas of combinatorial transcriptional regulation in mouse and man.Cell 2010 03 5;140(5):744-52
Molecular Functions
DNA binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, protein binding, zinc ion binding
Protein Domains
A domain family that is part of the cupin metalloenzyme superfamily, ARID/BRIGHT DNA binding domain, C5HC2 zinc finger, JmjC domain, jmjN domain, PHD-finger, PLU-1-like protein, protein binding