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GLUD2 - glutamate dehydrogenase 2
Entrez Gene Name: glutamate dehydrogenase 2
Entrez GeneID: Human(2747)
, Mouse(104277)
, Mouse(104277) Synonyms: EG545999, GDH2, GLUD2, GLUDP1, Gm5902, LOC638434
Gene Summary
- Human (2747): The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
| Disease:
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Biological Process
cellular amino acid metabolic process, glutamate biosynthetic process, glutamate catabolic process, glutamate metabolic process, oxidation-reduction process
Literature References
- 17507377Choi MM, Kim EA, Yang SJ, Choi SY, Cho SW, Huh JW. Amino acid changes within antenna helix are responsible for different regulatory preferences of human glutamate dehydrogenase isozymes.J Biol Chem 2007 Jul 06;282(27):19510-7
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 21600947Karaca M, Frigerio F, Maechler P. From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis.Neurochem Int 2011 Sep 01;59(4):510-7
Molecular Functions
ADP binding, binding, glutamate dehydrogenase NAD(P)+ activity, glutamate dehydrogenase activity, GTP binding, leucine binding, oxidoreductase activity
Protein Domains
ADP binding, enzyme, Glu/Leu/Phe/Val dehydrogenase, dimerisation domain, glutamate dehydrogenase, glutamate dehydrogenase NAD(P) , Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, GTP binding, Rossmann-fold NAD(P)(+)-binding proteins