WASL (includes EG:8976) - Wiskott-Aldrich syndrome-like
Entrez Gene Name: Wiskott-Aldrich syndrome-like
Entrez GeneID: Human(8976)
, Mouse(73178)
, Mouse(73178) Synonyms: 2900021I12Rik, 3110031I02Rik, DKFZp779G0847, MGC48327, N-WASP, WASL (includes EG:8976)
Gene Summary
- Human (8976): The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
|
Biological Process
actin nucleation, actin polymerization or depolymerization, cell motion, cell projection assembly, protein complex assembly, regulation of transcription, DNA-dependent, response to bacterium, transcription
Literature References
- 12437929Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA. Structure of the N-WASP EVH1 Domain-WIP Complex. Insight into the Molecular Basis of Wiskott-Aldrich Syndrome.Cell 2002 Nov 15;111(4):565-76
- 11395419Higgs HN, Pollard TD. Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.Annu Rev Biochem 2001;70:649-76
- 10358777Snapper SB, Rosen FS. The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization.Annu Rev Immunol 1999;17:905-29 View 493 categorized literature findings and their references in IPA
Protein Domains
basic domain, CDC42/Rac interactive binding domain, GTPase binding domain, Ilimaquionone motif, protein binding, small GTPase regulatory/interacting protein, VCA domain, WASP homology 1 domain, WASP homology domain 2
Subcellular Locations
actin filaments, cell cortex, cell membrane leading edge, cytoplasm, cytosol, cytosolic fraction, nucleus, perinuclear region
