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CASP1 - caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Entrez Gene Name: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Entrez GeneID: Human(834)
, Mouse(12362), Rat(25166)
, Mouse(12362), Rat(25166) Synonyms: CASP1, CASPASE-1, ICE, IL1BC, interleukin 1-beta convertase, interleukin-1beta converting enzyme, P45, p45 ICE
Gene Summary
- Human (834): This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq]
- Rat (25166): apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of caspase activity, apoptosis, cell death, cellular response to mechanical stimulus, cellular response to organic substance, induction of apoptosis, interleukin-1 beta production, lung development, memory, metabolic process, microglial cell activation, midgut development, myoblast fusion, positive regulation of apoptosis, positive regulation of circadian sleep/wake cycle, non-REM sleep, positive regulation of cytokine secretion, positive regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of interleukin-1 alpha secretion, positive regulation of interleukin-1 beta secretion, protein processing, proteolysis, regulation of apoptosis, response to ATP, response to chemical stimulus, response to drug, response to hypoxia, response to lipopolysaccharide, response to organic cyclic compound, response to toxin, signal transduction
Literature References
- 20303296Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.Immunity 2010 Mar 26;32(3):379-91
- 20303877Nathan C, Ding A. Nonresolving inflammation.Cell 2010 Mar 19;140(6):871-82
- 20303871Zitvogel L, Kepp O, Kroemer G. Decoding cell death signals in inflammation and immunity.Cell 2010 Mar 19;140(6):798-804
Molecular Functions
caspase activator activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding
Protein Domains
active site, CASc, caspase, caspase activator, catalytic domain, peptidase, pro domain, protein binding, The Death Domain Superfamily of protein-protein interaction domains