KIR2DL3 - killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Entrez Gene Name: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Entrez GeneID: Human(3804)
Synonyms: CD158B, CD158B2, GL183, KIR-023GB, KIR-K7b, KIR-K7c, KIR2DL3, KIRCL23, MGC129943, NKAT, NKAT2, NKAT2A, NKAT2B, p58
Gene Summary
- Human (3804): Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 15217996Yang JH, Chen MJ, Chen HF, Lee TH, Ho HN, Yang YS. Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis.Hum Reprod 2004 Sep 01;19(9):1974-8
- 15845448Feng J, Garrity D, Call ME, Moffett H, Wucherpfennig KW. Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors.Immunity 2005 Apr 01;22(4):427-38
- 10092767Bruhns P, Marchetti P, Fridman WH, Vivier E, Daeron M. Differential roles of N- and C-terminal immunoreceptor tyrosine-based inhibition motifs during inhibition of cell activation by killer cell inhibitory receptors.J Immunol 1999 Mar 15;162(6):3168-75 View 116 categorized literature findings and their references in IPA
Protein Domains
antigen binding, cytosolic tail domain, immunoglobulin domain, immunoreceptor tyrosine-based inhibition motif, receptor
