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DVL1 - dishevelled, dsh homolog 1 (Drosophila)

Entrez Gene Name: dishevelled, dsh homolog 1 (Drosophila)
Synonyms: DISHEVELED, Dsh, DVL, DVL1, DVL1L1, KIAA4029, MGC54245, mKIAA4029

Gene Summary

  • Human (1855): DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
  • Rat (83721): mouse homolog contributes to social and sensorimotor behavior [RGD, Feb 2006]

Cell Regulation

Regulates:
  • GSK3B
  • CTNNB1
  • MAPK8
View all 52 in IPA
Regulated by:
  • Frizzled
  • FZD2
  • MARK2
View all 36 in IPA
Binds:
  • AXIN1
  • FRAT1
  • DACT1
View all 70 in IPA
Role in cell:
  • development
  • guidance
  • extension
View all 26 in IPA
Disease:
  • productive infection by HIV-1 group M
  • leiomyomatosis
View all 4 in IPA

Biological Process

axon extension, axon guidance, axonogenesis, canonical Wnt receptor signaling pathway, cochlea morphogenesis, collateral sprouting, convergent extension, convergent extension involved in neural plate elongation, convergent extension involved in organogenesis, cytoplasmic microtubule organization, dendrite morphogenesis, heart development, intracellular signal transduction, multicellular organismal development, negative regulation of protein binding, negative regulation of protein kinase activity, negative regulation of protein phosphorylation, neural tube development, neuromuscular junction development, neurotransmitter secretion, planar cell polarity pathway involved in neural tube closure, positive regulation of canonical Wnt receptor signaling pathway, positive regulation of neuron projection development, positive regulation of transcription, DNA-dependent, positive regulation of Wnt receptor signaling pathway, prepulse inhibition, protein localization to microtubule, protein localization to nucleus, receptor clustering, regulation of neurotransmitter levels, regulation of protein phosphorylation, regulation of signaling, signal transduction, skeletal muscle nicotinic acetylcholine receptor clustering, social behavior, synapse organization, transcription from RNA polymerase II promoter, Wnt receptor signaling pathway, Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Components

axon, cell cortex, clathrin-coated vesicle, cytoplasm, cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, cytosol, dendrite, growth cone, intracellular, membrane, membrane fraction, microtubule, microtubule cytoskeleton, neuronal cell body, plasma membrane, soluble fraction, synapse, synaptosome

Literature References

  • 12165471Luo ZG, Wang Q, Zhou JZ, Wang J, Luo Z, Liu M, He X, Wynshaw-Boris A, Xiong WC, Lu B, Mei L. Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.Neuron 2002 Aug 1;35(3):489-505
  • 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 Jan 01;19(1):1-49
  • 16818724Ahmad-Annuar A, Ciani L, Simeonidis I, Herreros J, Fredj NB, Rosso SB, Hall A, Brickley S, Salinas PC. Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release.J Cell Biol 2006 Jul 03;174(1):127-39
View 628 categorized literature findings and their references in IPA

Molecular Functions

enzyme binding, frizzled binding, identical protein binding, protein binding, protein kinase binding, Rac GTPase binding, signal transducer activity

Protein Domains

DEP, DIX domain, enzyme binding, frizzled binding, identical protein binding, PDZ, protein binding, protein kinase binding

Subcellular Locations

actin filaments, actin stress fibers, apical membrane, axons, basal membrane, cell membrane leading edge, cell surface, cell-cell contacts, clathrin-coated vesicles, Cytoplasm, cytoplasmic particles, cytoplasmic vesicles, cytosol, cytosolic fraction, dendrites, focal adhesions, growth cone, intracellular storage compartment, lateral plasma membrane, membrane fraction, membrane processes, microtubule cytoskeleton, microtubules, Nucleus, perikaryon, perinuclear region, synapse, synaptosomal fractions, synaptosomes