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PTEN - phosphatase and tensin homolog

Entrez Gene Name: phosphatase and tensin homolog
Synonyms: 10q23del, 2310035O07RIK, A130070J02Rik, AI463227, BZS, MGC11227, MHAM, Mmac, MMAC1, MUTATED IN MULTIPLE ADVANCED CANCERS, mutated in multiple advanced cancers 1, PTEN, PTEN1, TEP1

Gene Summary

  • Human (5728): This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]
  • Rat (50557): may be involved in regulation of phosphoinositide 3-kinase and Akt kinase mediated antiapoptotic pathways [RGD]

Cell Regulation

Regulates:
  • Akt
  • AKT1
  • CDKN1B
View all 445 in IPA
Regulated by:
  • TP53
  • RELA
  • PTEN
View all 168 in IPA
Binds:
  • MAGI2
  • PTK2
  • MVP
View all 67 in IPA
Role in cell:
  • apoptosis
  • growth
  • proliferation
View all 67 in IPA
Disease:
  • neoplasia
  • cancer
  • tumorigenesis
View all 67 in IPA

Biological Process

aging, angiogenesis, cardiac muscle tissue development, cell cycle, cell migration, central nervous system development, endothelial cell migration, heart development, induction of apoptosis, inositol phosphate dephosphorylation, lipid metabolic process, memory, negative regulation of apoptosis, negative regulation of cell cycle, negative regulation of cell migration, negative regulation of cell proliferation, negative regulation of focal adhesion formation, negative regulation of phagocytosis, negative regulation of protein kinase B signaling cascade, neuron projection development, phosphoinositide dephosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of apoptosis, protein amino acid dephosphorylation, regulation of cyclin-dependent protein kinase activity, regulation of protein stability, response to arsenic, response to ATP, response to drug, response to estradiol stimulus, response to ethanol, response to glucose stimulus, response to inorganic substance, response to nutrient, response to organic cyclic substance, response to organic substance, response to zinc ion

Cellular Components

cytoplasm, cytosol, mitochondrion, nucleus

Literature References

  • 17218252Baker SJ. PTEN Enters the Nuclear Age.Cell 2007 Jan 12;128(1):25-8
  • 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
  • 16107612Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.Genes Dev 2005 Sep 01;19(17):2054-65
View 3566 categorized literature findings and their references in IPA

Molecular Functions

hydrolase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity, lipid binding, magnesium ion binding, PDZ domain binding, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphatase activity, platelet-derived growth factor receptor binding, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity

Protein Domains

C2 domain, catalytic domain, inositol/phosphatidylinositol phosphatase, pdz domain, PDZ-domain binding, PEST domain, phosphatase, phosphatase domain, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphatase, platelet-derived growth factor receptor binding, protein binding, protein serine/threonine phosphatase, protein tyrosine/serine/threonine phosphatase, protein-tyrosine-phoshatase, tail domain

Subcellular Locations

axons, cytoplasm, cytoplasmic fraction, cytosol, granules, membrane rafts, membrane surface, nuclear fraction, nucleoplasm, nucleus, plasma membrane