PTEN - phosphatase and tensin homolog
Entrez Gene Name: phosphatase and tensin homolog
Entrez GeneID: Human(5728)
, Mouse(19211), Rat(50557)
, Mouse(19211), Rat(50557) Synonyms: 10q23del, 2310035O07RIK, A130070J02Rik, AI463227, BZS, MGC11227, MHAM, Mmac, MMAC1, MUTATED IN MULTIPLE ADVANCED CANCERS, mutated in multiple advanced cancers 1, PTEN, PTEN1, TEP1
Gene Summary
- Human (5728): This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]
- Rat (50557): may be involved in regulation of phosphoinositide 3-kinase and Akt kinase mediated antiapoptotic pathways [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
aging, angiogenesis, cardiac muscle tissue development, cell cycle, cell migration, central nervous system development, endothelial cell migration, heart development, induction of apoptosis, inositol phosphate dephosphorylation, lipid metabolic process, memory, negative regulation of apoptosis, negative regulation of cell cycle, negative regulation of cell migration, negative regulation of cell proliferation, negative regulation of focal adhesion formation, negative regulation of phagocytosis, negative regulation of protein kinase B signaling cascade, neuron projection development, phosphoinositide dephosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of apoptosis, protein amino acid dephosphorylation, regulation of cyclin-dependent protein kinase activity, regulation of protein stability, response to arsenic, response to ATP, response to drug, response to estradiol stimulus, response to ethanol, response to glucose stimulus, response to inorganic substance, response to nutrient, response to organic cyclic substance, response to organic substance, response to zinc ion
Literature References
- 17218252Baker SJ. PTEN Enters the Nuclear Age.Cell 2007 Jan 12;128(1):25-8
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 16107612Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.Genes Dev 2005 Sep 01;19(17):2054-65
Molecular Functions
hydrolase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity, lipid binding, magnesium ion binding, PDZ domain binding, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphatase activity, platelet-derived growth factor receptor binding, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity
- Insulin Receptor Signaling
- FAK Signaling
- Melanoma Signaling
- Tight Junction Signaling
- PTEN Signaling
- Hypoxia Signaling in the Cardiovascular System
- Inositol Phosphate Metabolism
- B Cell Receptor Signaling
- ILK Signaling
- RAR Activation
- Glioma Signaling
- Integrin Signaling
- Small Cell Lung Cancer Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- p53 Signaling
- Neuregulin Signaling
- Prostate Cancer Signaling
- Endometrial Cancer Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- PI3K/AKT Signaling
Protein Domains
C2 domain, catalytic domain, inositol/phosphatidylinositol phosphatase, pdz domain, PDZ-domain binding, PEST domain, phosphatase, phosphatase domain, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphatase, platelet-derived growth factor receptor binding, protein binding, protein serine/threonine phosphatase, protein tyrosine/serine/threonine phosphatase, protein-tyrosine-phoshatase, tail domain
Subcellular Locations
axons, cytoplasm, cytoplasmic fraction, cytosol, granules, membrane rafts, membrane surface, nuclear fraction, nucleoplasm, nucleus, plasma membrane
