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PTEN - phosphatase and tensin homolog
Entrez Gene Name: phosphatase and tensin homolog
Entrez GeneID: Human(5728)
, Mouse(19211), Rat(50557)
, Mouse(19211), Rat(50557) Synonyms: 10q23del, 2310035O07RIK, A130070J02Rik, AI463227, B430203M17RIK, BZS, DEC, GLM2, MGC11227, MGC183880, MHAM, Mmac, MMAC1, MUTATED IN MULTIPLE ADVANCED CANCERS, mutated in multiple advanced cancers 1, PTEN, PTEN1, TEP1
Gene Summary
- Human (5728): This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Rat (50557): may be involved in regulation of phosphoinositide 3-kinase and Akt kinase mediated antiapoptotic pathways [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of mitotic anaphase-promoting complex activity, aging, angiogenesis, apoptosis, canonical Wnt receptor signaling pathway, cardiac muscle tissue development, cell migration, cell proliferation, central nervous system development, dephosphorylation, endothelial cell migration, fibroblast growth factor receptor signaling pathway, heart development, induction of apoptosis, inositol phosphate dephosphorylation, lipid metabolic process, long term synaptic depression, memory, negative regulation of apoptosis, negative regulation of cell aging, negative regulation of cell migration, negative regulation of cell proliferation, negative regulation of cyclin-dependent protein kinase activity involved in G1/S, negative regulation of epithelial cell proliferation, negative regulation of focal adhesion assembly, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of phagocytosis, negative regulation of protein kinase B signaling cascade, negative regulation of protein phosphorylation, nerve growth factor receptor signaling pathway, nervous system development, neuron projection development, peptidyl-tyrosine dephosphorylation, phosphatidylinositol dephosphorylation, phosphatidylinositol-mediated signaling, platelet-derived growth factor receptor signaling pathway, positive regulation of apoptosis, positive regulation of cell proliferation, positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, positive regulation of sequence-specific DNA binding transcription factor activity, prostate gland growth, protein dephosphorylation, protein stabilization, regulation of B cell apoptosis, regulation of cell cycle, regulation of cyclin-dependent protein kinase activity, regulation of myeloid cell apoptosis, regulation of neuron projection development, regulation of protein stability, response to arsenic-containing substance, response to ATP, response to drug, response to estradiol stimulus, response to ethanol, response to glucose stimulus, response to inorganic substance, response to nutrient, response to organic cyclic compound, response to organic substance, response to zinc ion, T cell receptor signaling pathway
Cellular Components
cytoplasm, cytosol, dendritic spine, internal side of plasma membrane, mitochondrion, myelin sheath, myelin sheath adaxonal region, nucleus, PML body, postsynaptic membrane, Schmidt-Lanterman incisure, synaptosome
Literature References
- 21642990Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, Khan AA, Setti M, Rondou P, Vandenberghe P, Delabesse E, Benoit Y, Socci NB, Leslie CS, Van Vlierberghe P, Speleman F, Wendel HG. A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Nat Genet 2011 Jan 01;43(7):673-8
- 17218252Baker SJ. PTEN Enters the Nuclear Age.Cell 2007 Jan 12;128(1):25-8
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
Molecular Functions
anaphase-promoting complex binding, enzyme binding, hydrolase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity, lipid binding, magnesium ion binding, PDZ domain binding, phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphatase activity, phosphoprotein phosphatase activity, platelet-derived growth factor receptor binding, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity
- Sertoli Cell-Sertoli Cell Junction Signaling
- Neuregulin Signaling
- ILK Signaling
- Tight Junction Signaling
- Hereditary Breast Cancer Signaling
- Inositol Phosphate Metabolism
- Hypoxia Signaling in the Cardiovascular System
- FAK Signaling
- Ovarian Cancer Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Melanoma Signaling
- Glioblastoma Multiforme Signaling
- Endometrial Cancer Signaling
- Insulin Receptor Signaling
- IL-17A Signaling in Airway Cells
- iCOS-iCOSL Signaling in T Helper Cells
- PI3K/AKT Signaling
- Small Cell Lung Cancer Signaling
- Role of Tissue Factor in Cancer
- PTEN Signaling
- Glioma Signaling
- p53 Signaling
- Integrin Signaling
- B Cell Receptor Signaling
- PI3K Signaling in B Lymphocytes
- Prostate Cancer Signaling
- RAR Activation
Protein Domains
C2 domain of PTEN tumour-suppressor protein, catalytic domain, enzyme binding, inositol/phosphatidylinositol phosphatase, lipid phosphatase domain, nuclear localization sequence, PDZ binding motif, PDZ-domain binding, PEST domain, phosphatase, phosphatase domain, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, phosphatidylinositol-3-phosphatase, phosphorylation site, platelet-derived growth factor receptor binding, protein binding, protein phosphatase, protein serine/threonine phosphatase, protein tyrosine/serine/threonine phosphatase, protein-tyrosine-phoshatase, PTPase domain, PTPc, tail domain
Subcellular Locations
axons, Cytoplasm, cytoplasmic face of plasma membrane, cytoplasmic fraction, cytosol, dendritic spines, granules, membrane rafts, membrane surface, mitochondria, nuclear fraction, nucleoplasm, Nucleus, Plasma Membrane, postsynaptic membrane, synaptosomes