SLC6A4 - solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Entrez Gene Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Entrez GeneID: Human(6532)
, Mouse(15567), Rat(25553)
, Mouse(15567), Rat(25553) Synonyms: 5-HT TRANSPORTER, 5-HTT, 5-HTTLPR, AI323329, hSERT, HTT, MGC124313, MGC124314, OCD1, serotonin transporter, SERT, SLC6A4, SOLUTE CARRIER FAMILY 6, MEMBER 4
Gene Summary
- Human (6532): This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq]
- Rat (25553): binds serotonin; may play a role in regulation of motor activity [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
locomotory behavior, monoamine transport, neurotransmitter transport, neurotransmitter uptake, serotonin transport, serotonin uptake, transport
Cellular Components
integral to membrane, integral to plasma membrane, membrane, membrane fraction, membrane raft
Literature References
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
- 17913921Zhang YW, Gesmonde J, Ramamoorthy S, Rudnick G. Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder.J Neurosci 2007 Oct 03;27(40):10878-86
- 17452640Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J, Marin P. From the Cover: Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.Proc Natl Acad Sci U S A 2007 May 08;104(19):8119-24 View 959 categorized literature findings and their references in IPA
Molecular Functions
cocaine binding, monoamine transmembrane transporter activity, neurotransmitter:sodium symporter activity, protein binding, protein homodimerization activity, serotonin transmembrane transporter activity, serotonin:sodium symporter activity, symporter activity
Protein Domains
carboxy terminal domain, cocaine binding, intracellular domain, monoamine transporter, protein binding, protein homodimerization, serotonin transporter, transporter
Subcellular Locations
apical cell surfaces, axons, cell surface, cellular membrane, intracellular space, membrane fraction, membrane rafts, plasma membrane, raft fractions, synaptosomes
