ACTC1 - actin, alpha, cardiac muscle 1
Entrez Gene Name: actin, alpha, cardiac muscle 1
Entrez GeneID: Human(70)
, Mouse(11464), Rat(29275)
, Mouse(11464), Rat(29275) Synonyms: ACTC, ACTC1, CARDIAC ALPHA ACTIN, CMD1R, CMH11, MGC156490
Gene Summary
- Human (70): Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq]
- Rat (29275): may act as a structural component of the cytoskeleton; may play a role in muscle function [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actin filament-based movement, actomyosin structure organization, apoptosis, cardiac muscle contraction, cardiac muscle tissue morphogenesis, cardiac myofibril assembly, heart contraction, muscle thin filament assembly, response to drug, response to ethanol
Literature References
- 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 14592989Stuven T, Hartmann E, Gorlich D. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.EMBO J 2003 11 3;22(21):5928-40 View 2926 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATPase activity, myosin binding, nucleotide binding, protein binding
- Clathrin-mediated Endocytosis Signaling
- Actin Cytoskeleton Signaling
- Regulation of Actin-based Motility by Rho
- Tight Junction Signaling
- NRF2-mediated Oxidative Stress Response
- FAK Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Leukocyte Extravasation Signaling
- Integrin Signaling
- Mechanisms of Viral Exit from Host Cells
- Agrin Interactions at Neuromuscular Junction
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Caveolar-mediated Endocytosis Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Cellular Effects of Sildenafil (Viagra)
- Calcium Signaling
- Virus Entry via Endocytic Pathways
- ILK Signaling
- Purine Metabolism
- VEGF Signaling
Protein Domains
ATP binding, ATPase, motor protein, myosin binding, protein binding, structural constituent of muscle
