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WNT1 - wingless-type MMTV integration site family, member 1
Entrez Gene Name: wingless-type MMTV integration site family, member 1
Entrez GeneID: Human(7471)
, Mouse(22408), Rat(24881)
, Mouse(22408), Rat(24881) Synonyms: INT1, sw, swaying, Wg, WNT1
Gene Summary
- Human (7471): The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
- Rat (24881): mouse homolog promotes development of midbrain dopaminergic (DA) neurons [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
axis specification, BMP signaling pathway, brain segmentation, branching involved in ureteric bud morphogenesis, canonical Wnt receptor signaling pathway, canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis, cell-cell signaling, cellular response to peptide hormone stimulus, central nervous system morphogenesis, cerebellum formation, cerebellum morphogenesis, dermatome development, diencephalon development, embryonic axis specification, embryonic pattern specification, forebrain anterior/posterior pattern formation, fourth ventricle development, hemopoietic stem cell proliferation, hepatocyte differentiation, inner ear morphogenesis, mesoderm morphogenesis, metencephalon development, midbrain development, midbrain-hindbrain boundary development, midbrain-hindbrain boundary maturation during brain development, multicellular organismal development, myoblast fusion, myotube differentiation, negative regulation of apoptosis, negative regulation of cell aging, negative regulation of cell-cell adhesion, negative regulation of cell-substrate adhesion, negative regulation of DNA damage checkpoint, negative regulation of fat cell differentiation, negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, negative regulation of transcription from RNA polymerase II promoter, negative regulation of transforming growth factor beta receptor signaling pathway, neuron fate commitment, neuron fate determination, organ morphogenesis, organ regeneration, positive regulation of cell proliferation, positive regulation of fibroblast proliferation, positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of lamellipodium assembly, positive regulation of Notch signaling pathway, positive regulation of protein phosphorylation, positive regulation of sequence-specific DNA binding transcription factor activity, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-dependent, response to wounding, signal transduction, signal transduction in response to DNA damage, Spemann organizer formation, spinal cord association neuron differentiation, T cell differentiation in thymus, ubiquitin-dependent SMAD protein catabolic process, Wnt receptor signaling pathway, Wnt receptor signaling pathway, calcium modulating pathway
Cellular Components
cell surface, cytoplasm, early endosome, extracellular region, extracellular space, late endosome, membrane raft, plasma membrane, proteinaceous extracellular matrix
Literature References
- 11055431Rodriguez CI, Dymecki SM. Origin of the precerebellar system.Neuron 2000 Sep 1;27(3):475-86
- 20710043Kumar R, Balasenthil S, Pakala SB, Rayala SK, Sahin AA, Ohshiro K. Metastasis-associated protein 1 short form stimulates wnt1 pathway in mammary epithelial and cancer cells.Cancer Res 2010 Aug 15;70(16):6598-608
- 20501844Pond AC, Herschkowitz JI, Schwertfeger KL, Welm B, Zhang Y, York B, Cardiff RD, Hilsenbeck S, Perou CM, Creighton CJ, Lloyd RE, Rosen JM. Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.Cancer Res 2010 Jun 15;70(12):4868-79
Molecular Functions
cytokine activity, frizzled binding, frizzled-2 binding, protein binding, protein domain specific binding, receptor binding, transcription regulatory region DNA binding
- Colorectal Cancer Metastasis Signaling
- Ovarian Cancer Signaling
- Axonal Guidance Signaling
- Glioblastoma Multiforme Signaling
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Molecular Mechanisms of Cancer
- Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza
- Human Embryonic Stem Cell Pluripotency
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Wnt/β-catenin Signaling
- Basal Cell Carcinoma Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
Protein Domains
cytokine, found in Wnt-1, protein binding, protein domain specific binding, receptor binding, wnt family