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YAP1 - Yes-associated protein 1
Entrez Gene Name: Yes-associated protein 1
Entrez GeneID: Human(10413)
, Mouse(22601), Rat(363014)
, Mouse(22601), Rat(363014) Synonyms: AI325207, YAP, YAP1, YAP2, YAP65, YKI, Yorkie
Gene Summary
- Human (10413): This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq]
- Mouse (22601): This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell proliferation, cellular response to gamma radiation, contact inhibition, DNA damage induced protein phosphorylation, embryonic heart tube morphogenesis, hippo signaling cascade, keratinocyte differentiation, lateral mesoderm development, negative regulation of apoptosis, negative regulation of epithelial cell differentiation, notochord development, paraxial mesoderm development, positive regulation of canonical Wnt receptor signaling pathway, positive regulation of cell proliferation, positive regulation of organ growth, positive regulation of transcription from RNA polymerase II promoter, regulation of cell proliferation, regulation of keratinocyte proliferation, regulation of stem cell proliferation, regulation of transcription, DNA-dependent, response to DNA damage stimulus, somatic stem cell maintenance, transcription from RNA polymerase II promoter, transcription, DNA-dependent, vasculogenesis
Literature References
- 11358867Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.Genes Dev 2001 May 15;15(10):1229-41
- 17502622Kulman JD, Harris JE, Xie L, Davie EW. Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein.Proc Natl Acad Sci U S A 2007 May 22;104(21):8767-72
- 16354681Morin-Kensicki EM, Boone BN, Howell M, Stonebraker JR, Teed J, Alb JG, Magnuson TR, O'neal W, Milgram SL. Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of yap65.Mol Cell Biol 2006 Jan 01;26(1):77-87
Molecular Functions
chromatin binding, proline-rich region binding, protein binding, RNA polymerase II transcription factor binding transcription factor activity, transcription coactivator activity, transcription corepressor activity, transcription regulatory region DNA binding
Protein Domains
14-3-3 binding domain, Akt phosphorylation site, chromatin binding, ligand-binding domain, proline tyrosine motif, protein binding, transcription co-activator, transcription co-repressor, transcription regulator, WW