ADRBK2 - adrenergic, beta, receptor kinase 2
Entrez Gene Name: adrenergic, beta, receptor kinase 2
Entrez GeneID: Human(157)
, Mouse(320129), Rat(25372)
, Mouse(320129), Rat(25372) Synonyms: 4833444A01RIK, ADRBK2, AI851927, AW551196, BARK2, BETA ARK2, FLJ31125, GRK3
Gene Summary
- Human (157): The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq]
- Rat (25372): catalzyes phosphorylation of the beta-adrenergic receptor; may mediate desensitizaton of synaptic receptors; may regulate bone formation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
desensitization of G-protein coupled receptor protein signaling pathway, negative regulation of G-protein coupled receptor protein signaling pathway, phosphorylation, protein amino acid phosphorylation, signal transduction
Literature References
- 9759500Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases.Annu Rev Biochem 1998;67:653-92
- 17255468Salim S, Standifer KM, Eikenburg DC. Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of g-protein-coupled receptor kinase 3 expression in neuronal cells.J Pharmacol Exp Ther 2007 Apr 01;321(1):51-9
- 11100733Nishida M, Maruyama Y, Tanaka R, Kontani K, Nagao T, Kurose H. G alpha(i) and G alpha(o) are target proteins of reactive oxygen species.Nature 2000 Nov 23;408(6811):492-5 View 283 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, beta-2 adrenergic receptor binding, beta-adrenergic receptor kinase activity, G-protein coupled receptor kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, signal transducer activity, transferase activity
Protein Domains
Beta-adrenergic-receptor kinase, carboxy terminal domain, G-protein coupled receptor kinase, kinase, pleckstrin homology (PH) domain, protein serine/threonine kinase, RGS domain
Subcellular Locations
cytoplasm, cytosol, cytosolic fraction, postsynaptic density, presynaptic regions
