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CELA1 - chymotrypsin-like elastase family, member 1
Canonical
Pathway
Entrez Gene Name: chymotrypsin-like elastase family, member 1
Entrez GeneID: Human(1990)
, Mouse(109901), Rat(24331)
, Mouse(109901), Rat(24331) Synonyms: 1810009A17Rik, 1810062B19Rik, CELA1, ELA1, ELAI1, Elastase1, PC-TsF, RATELAI1
Gene Summary
- Human (1990): Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq]
- Rat (24331): catalyzes the hydrolysis of elastin and other proteins [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
digestive system development, exocrine pancreas development, inflammatory response, multicellular organism growth, negative regulation of transcription from RNA polymerase II promoter, pancreas morphogenesis, positive regulation of transcription from RNA polymerase II promoter, post-embryonic development, proteolysis, regulation of cell differentiation, regulation of cell proliferation, Wnt receptor signaling pathway
Literature References
- 16940214Shiraya S, Miwa K, Aoki M, Miyake T, Oishi M, Kataoka K, Ohgi S, Ogihara T, Kaneda Y, Morishita R. Hypertension accelerated experimental abdominal aortic aneurysm through upregulation of nuclear factor kappaB and Ets.Hypertension 2006 Oct 01;48(4):628-36
- 16354684Beres TM, Masui T, Swift GH, Shi L, Henke RM, Macdonald RJ. PTF1 Is an Organ-Specific and Notch-Independent Basic Helix-Loop-Helix Complex Containing the Mammalian Suppressor of Hairless (RBP-J) or Its Paralogue, RBP-L.Mol Cell Biol 2006 Jan 01;26(1):117-30
- 15161642Fontaine V, Touat Z, Mtairag el M, Vranckx R, Louedec L, Houard X, Andreassian B, Sebbag U, Palombi T, Jacob MP, Meilhac O, Michel JB. Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus.Am J Pathol 2004 Jun 01;164(6):2077-87
Molecular Functions
hydrolase activity, metal ion binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity