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SOD2 - superoxide dismutase 2, mitochondrial
Entrez Gene Name: superoxide dismutase 2, mitochondrial
Entrez GeneID: Human(6648)
, Mouse(20656), Rat(24787)
, Mouse(20656), Rat(24787) Synonyms: IPOB, MANGANESE DEPENDENT SOD, Manganese Superoxide Dismutase 2, MGC128371, MGC5618, MGC6144, MITOCHONDRIAL SOD, Mn superoxide dismutase, MNSOD, mtSOD, MVCD6, SOD2
Gene Summary
- Human (6648): This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
- Rat (24787): manganese superoxide dismutase; intramitochondrial free radical scavenging enzyme [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
age-dependent response to oxidative stress, age-dependent response to reactive oxygen species, aging, anti-apoptosis, apoptosis, cellular response to ethanol, detection of oxygen, erythrophore differentiation, glutathione metabolic process, heart development, hemopoiesis, hydrogen peroxide biosynthetic process, hydrogen peroxide metabolic process, iron ion homeostasis, liver development, locomotory behavior, mitochondrion organization, negative regulation of apoptosis, negative regulation of cell proliferation, negative regulation of fat cell differentiation, negative regulation of fibroblast proliferation, negative regulation of neuron apoptosis, neuron development, oxidation-reduction process, oxygen homeostasis, positive regulation of nitric oxide biosynthetic process, post-embryonic development, protein homooligomerization, protein homotetramerization, regulation of blood pressure, regulation of catalytic activity, regulation of mitochondrial membrane potential, regulation of transcription from RNA polymerase II promoter, release of cytochrome c from mitochondria, removal of superoxide radicals, respiratory electron transport chain, response to activity, response to axon injury, response to cadmium ion, response to drug, response to electrical stimulus, response to gamma radiation, response to hydrogen peroxide, response to hyperoxia, response to hypoxia, response to L-ascorbic acid, response to lipopolysaccharide, response to manganese ion, response to nutrient levels, response to oxidative stress, response to reactive oxygen species, response to selenium ion, response to silicon dioxide, response to stress, response to superoxide, response to zinc ion, sensory perception of sound, superoxide anion generation, superoxide metabolic process, vasodilation, vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
Cellular Components
cytoplasm, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, soluble fraction
Literature References
- 11182078Sherman MY, Goldberg AL. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases.Neuron 2001 Jan 01;29(1):15-32
- 20351176Roy N, Stoyanova T, Dominguez-Brauer C, Park HJ, Bagchi S, Raychaudhuri P. DDB2, an essential mediator of premature senescence.Mol Cell Biol 2010 Jun 01;30(11):2681-92
- 20195357Miyamoto-Sato E, Fujimori S, Ishizaka M, Hirai N, Masuoka K, Saito R, Ozawa Y, Hino K, Washio T, Tomita M, Yamashita T, Oshikubo T, Akasaka H, Sugiyama J, Matsumoto Y, Yanagawa H. A comprehensive resource of interacting protein regions for refining human transcription factor networks.PLoS One 2010 01 1;5(2):e9289
Molecular Functions
DNA binding, identical protein binding, manganese ion binding, metal ion binding, oxidoreductase activity, oxygen binding, protein binding, superoxide dismutase activity
Protein Domains
DNA binding, enzyme, identical protein binding, Iron/manganese superoxide dismutases, alpha-hairpin domain, Iron/manganese superoxide dismutases, C-terminal domain, manganese ion binding, mitochondrial presequence, oxygen binding, protein binding, superoxide dismutase
Subcellular Locations
cellular membrane, Cytoplasm, mitochondria, mitochondrial fraction, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoids, myelin enriched fraction, nuclear fraction, perinuclear region, peroxisomal fraction, soluble fraction