CHRM1 - cholinergic receptor, muscarinic 1
Entrez Gene Name: cholinergic receptor, muscarinic 1
Entrez GeneID: Human(1128)
, Mouse(12669), Rat(25229)
, Mouse(12669), Rat(25229) Synonyms: Achr, CHRM1, HM1, M1, M1 MACHR, M1 MUSCARINIC RECEPTOR, M1R, MGC30125, MUSCARINIC RECEPTOR SUBTYPE 1
Gene Summary
- Human (1128): The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq]
- Rat (25229): plays a role in acetylcholine receptor signaling and neuromuscular synaptic transmission [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway, activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, G-protein coupled receptor protein signaling pathway, muscarinic acetylcholine receptor signaling pathway, nervous system development, neuromuscular synaptic transmission, positive regulation of cell proliferation, protein modification process, regulation of locomotion, signal transduction
Cellular Components
asymmetric synapse, cell junction, dendrite, integral to membrane, integral to plasma membrane, membrane, membrane fraction, nerve terminal, plasma membrane, postsynaptic density, postsynaptic membrane, synapse
Literature References
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 18499672Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, Matsuda T, Seki T, Sakai N, Saito N. Enzymological Analysis of Mutant Protein Kinase C{gamma} Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+ Homeostasis.J Biol Chem 2008 Jul 11;283(28):19854-63
- 17222678Oki T, Kageyama A, Takagi Y, Uchida S, Yamada S. Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder.J Urol 2007 Feb 01;177(2):766-70 View 1125 categorized literature findings and their references in IPA
Molecular Functions
drug binding, G-protein coupled receptor activity, muscarinic acetylcholine receptor activity, phosphoinositide phospholipase C activity, receptor activity, signal transducer activity
