BAZ1B - bromodomain adjacent to zinc finger domain, 1B
Entrez Gene Name: bromodomain adjacent to zinc finger domain, 1B
Entrez GeneID: Human(9031)
, Mouse(22385), Rat(368002)
, Mouse(22385), Rat(368002) Synonyms: BAZ1B, Baz1b predicted, C87820, WBSCR10, WBSCR9, WSTF
Gene Summary
- Human (9031): This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulated by:
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Biological Process
chromatin assembly or disassembly, chromatin remodeling, histone phosphorylation, regulation of transcription, DNA-dependent, response to DNA damage stimulus, transcription
Cellular Components
centromeric heterochromatin, chromatin remodeling complex, condensed chromosome, nucleus
Literature References
- 12837248Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S. The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.Cell 2003 06 27;113(7):905-17
- 11980720Bozhenok L, Wade PA, Varga-Weisz P. WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.EMBO J 2002 May 1;21(9):2231-41
- 15543136Poot RA, Bozhenok L, van den Berg DL, Steffensen S, Ferreira F, Grimaldi M, Gilbert N, Ferreira J, Varga-Weisz PD. The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci.Nat Cell Biol 2004 Dec 01;6(12):1236-44 View 72 categorized literature findings and their references in IPA
Molecular Functions
chromatin binding, histone acetyl-lysine binding, histone kinase activity, metal ion binding, protein binding, protein tyrosine kinase activity, transcription factor activity, zinc ion binding
Protein Domains
bromodomain, PHD domain, protein binding, transcription factor, transcription regulator, zinc ion binding
