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NUP98 - nucleoporin 98kDa
Canonical
Pathway
Entrez Gene Name: nucleoporin 98kDa
Entrez GeneID: Human(4928)
, Rat(81738)
, Rat(81738) Synonyms: 4732457F17, ADIR2, AI849286, MGC118567, NUP196, NUP96, NUP98
Gene Summary
- Human (4928): Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq]
- Rat (81738): nuclear pore complex protein; involved in nuclear pore complex docking and transport [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
carbohydrate metabolic process, DNA replication, glucose transport, hexose transport, interspecies interaction between organisms, M phase of mitotic cell cycle, mitotic cell cycle, mitotic prometaphase, mRNA transport, nuclear pore organization, nucleocytoplasmic transport, protein import into nucleus, docking, protein transport, regulation of glucose transport, transmembrane transport, viral reproduction
Cellular Components
cytosol, kinetochore, membrane, nuclear envelope, nuclear membrane, nuclear pore, nucleoplasm, nucleus, Nup107-160 complex
Literature References
- 20237320Argiropoulos B, Yung E, Xiang P, Lo CY, Kuchenbauer F, Palmqvist L, Reindl C, Heuser M, Sekulovic S, Rosten P, Muranyi A, Goh SL, Featherstone M, Humphries RK. Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.Blood 2010 May 20;115(20):4071-82
- 17178874Chung KY, Morrone G, Schuringa JJ, Plasilova M, Shieh JH, Zhang Y, Zhou P, Moore MA. Enforced Expression of NUP98-HOXA9 in Human CD34+ Cells Enhances Stem Cell Proliferation.Cancer Res 2006 Dec 15;66(24):11781-91
- 15608231Joshi-Tope G, Gillespie M, Vastrik I, D'Eustachio P, Schmidt E, de Bono B, Jassal B, Gopinath GR, Wu GR, Matthews L, Lewis S, Birney E, Stein L. Reactome: a knowledgebase of biological pathways.Nucleic Acids Res 2005 01 1;33(Database issue):D428-32
Molecular Functions
peptide binding, protein binding, structural constituent of nuclear pore, transporter activity
Protein Domains
Nuclear protein 96, Nucleoporin autopeptidase, peptide binding, protein binding, protein repeat, transporter
Subcellular Locations
centriole, cytosol, detergent-soluble fraction, intranuclear region, kinetochores, nuclear envelope, nuclear foci, nuclear fraction, nuclear membrane fraction, nuclear pores, nuclear rim, nucleoli, nucleoplasm, nucleoplasmic baskets, Nucleus, perinuclear region