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CBX1 - chromobox homolog 1
Canonical
Pathway
Entrez Gene Name: chromobox homolog 1
Entrez GeneID: Human(10951)
, Mouse(12412)
, Mouse(12412) Synonyms: CBX, Cbx-rs2, CBX1, E430007M08RIK, HETEROCHROMATIN PROTEIN p25, HP1-BETA, HP1B, HP1Hs-beta, M31, MOD1, Modifier 1, p25beta
Gene Summary
- Human (10951): This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Cellular Components
centromeric heterochromatin, chromatin, chromocenter, chromosome, centromeric region, female pronucleus, male pronucleus, nuclear heterochromatin, nucleoplasm, nucleus, spindle
Literature References
- 17470536Smallwood A, Estève PO, Pradhan S, Carey M. Functional cooperation between HP1 and DNMT1 mediates gene silencing.Genes Dev 2007 May 15;21(10):1169-78
- 12411497Nielsen AL, Sanchez C, Ichinose H, Cervino M, Lerouge T, Chambon P, Losson R. Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha.EMBO J 2002 Nov 1;21(21):5797-5806
- 11242053Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.Nature 2001 Mar 1;410(6824):116-20
Protein Domains
chromatin binding, CHROMO, ChSh, enzyme binding, identical protein binding, protein binding, transcription regulator
Subcellular Locations
centromeres, chromatin, chromosomes, Cytoplasm, mitotic spindle, nuclear chromatin, nuclear foci, nuclear fraction, nuclear rim, nucleoli, nucleoplasm, Nucleus, pericentric heterochromatin, pronucleus, sister chromatids, XY bodies