-
Product Directory
Custom Product
-
Services Offered
Custom Capabilities
-
VEGFA - vascular endothelial growth factor A
Entrez Gene Name: vascular endothelial growth factor A
Entrez GeneID: Human(7422)
, Mouse(22339), Rat(83785)
, Mouse(22339), Rat(83785) Synonyms: Gd-vegf, MGC70609, MVCD1, VEGF, Vegf-3, VEGF1, VEGF120, Vegf164, Vegf165, Vegf188, VEGFA, Vegfa 188, VPF, VPF/VEGF
Gene Summary
- Human (7422): This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq]
- Mouse (22339): This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. [provided by RefSeq]
- Rat (83785): This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiogenesis, anti-apoptosis, artery morphogenesis, basophil chemotaxis, behavior, blood coagulation, blood vessel development, blood vessel morphogenesis, blood vessel remodeling, branching morphogenesis of a tube, camera-type eye morphogenesis, cardiac muscle fiber development, cell differentiation, cell maturation, cell migration, cell proliferation, cellular response to hypoxia, cellular response to protein stimulus, epithelial cell differentiation, eye photoreceptor cell development, growth, heart morphogenesis, in utero embryonic development, induction of positive chemotaxis, kidney development, lactation, lung alveolus development, lung development, mammary gland alveolus development, mesoderm development, mRNA stabilization, multicellular organismal development, negative regulation of apoptosis, negative regulation of bone resorption, negative regulation of programmed cell death, nervous system development, ovarian follicle development, patterning of blood vessels, platelet activation, platelet degranulation, platelet-derived growth factor receptor signaling pathway, positive chemotaxis, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of cell adhesion, positive regulation of cell division, positive regulation of cell migration, positive regulation of cell proliferation, positive regulation of cellular component movement, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of leukocyte migration, positive regulation of mast cell chemotaxis, positive regulation of mesenchymal cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of positive chemotaxis, positive regulation of signal transduction, positive regulation of smooth muscle cell proliferation, positive regulation of transcription from RNA polymerase II promoter, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of vascular permeability, post-embryonic camera-type eye development, primitive erythrocyte differentiation, regulation of cell shape, response to cold, response to hypoxia, surfactant homeostasis, T-helper 1 type immune response, vascular endothelial growth factor receptor signaling pathway, vasculature development, vasculogenesis
Cellular Components
basement membrane, cell surface, cytoplasm, extracellular region, extracellular space, membrane, membrane-bounded vesicle, plasma membrane, platelet alpha granule lumen, proteinaceous extracellular matrix, stored secretory granule
Literature References
- 17339407Jiang Y, Reynolds C, Xiao C, Feng W, Zhou Z, Rodriguez W, Tyagi SC, Eaton JW, Saari JT, Kang YJ. Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice.J Exp Med 2007 Mar 19;204(3):657-66
- 12975317Zheng H, Wasylyk C, Ayadi A, Abecassis J, Schalken JA, Rogatsch H, Wernert N, Maira SM, Multon MC, Wasylyk B. The transcription factor Net regulates the angiogenic switch.Genes Dev 2003 Sep 15;17(18):2283-97
- 12682018Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G. The VHL protein recruits a novel KRAB-A domain protein to repress HIF- 1alpha transcriptional activity.EMBO J 2003 Apr 15;22(8):1857-67
Molecular Functions
cell surface binding, chemoattractant activity, cytokine activity, extracellular matrix binding, fibronectin binding, growth factor activity, heparin binding, platelet-derived growth factor receptor binding, protein binding, protein heterodimerization activity, protein homodimerization activity, vascular endothelial growth factor receptor 1 binding, vascular endothelial growth factor receptor 2 binding, vascular endothelial growth factor receptor binding
- Bladder Cancer Signaling
- Amyotrophic Lateral Sclerosis Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Inhibition of Angiogenesis by TSP1
- Role of Tissue Factor in Cancer
- mTOR Signaling
- Hypoxia Signaling in the Cardiovascular System
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- VEGF Signaling
- Ovarian Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- ILK Signaling
- IL-8 Signaling
- Clathrin-mediated Endocytosis Signaling
- RAR Activation
- Pancreatic Adenocarcinoma Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Corticotropin Releasing Hormone Signaling
- Renal Cell Carcinoma Signaling
- Ephrin Receptor Signaling
- HIF1α Signaling
- Relaxin Signaling
- Axonal Guidance Signaling
Protein Domains
cell surface binding, chemoattractant, cytokine, fibronectin binding, Flt-1 binding domain, growth factor, heparin binding, heparin binding domain, KDR binding domain, loop domain, PDGF, platelet-derived growth factor receptor binding, protein binding, protein heterodimerization, protein homodimerization, receptor binding domain, vascular endothelial growth factor receptor binding
Subcellular Locations
alpha granules, basement membrane, cell surface, Cytoplasm, cytosol, extracellular matrix, Extracellular Space, Nucleus, Plasma Membrane, secretory granules, secretory vesicles, vesicles