CBX1 - chromobox homolog 1 (HP1 beta homolog Drosophila )
Entrez Gene Name: chromobox homolog 1 (HP1 beta homolog Drosophila )
Entrez GeneID: Human(10951)
, Mouse(12412), Rat(360609)
, Mouse(12412), Rat(360609) Synonyms: CBX, Cbx-rs2, CBX1, E430007M08RIK, HETEROCHROMATIN PROTEIN p25, HP1-BETA, HP1B, HP1Hs-beta, M31, MOD1, Modifier1, p25beta, Similar to m31 or mod1
Gene Summary
- Human (10951): This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
chromatin assembly or disassembly, negative regulation of transcription, DNA-dependent
Cellular Components
centromeric heterochromatin, chromatin, chromocenter, chromosome, centromeric region, female pronucleus, male pronucleus, nuclear heterochromatin, nucleoplasm, nucleus, spindle
Literature References
- 17470536Smallwood A, Estève PO, Pradhan S, Carey M. Functional cooperation between HP1 and DNMT1 mediates gene silencing.Genes Dev 2007 May 15;21(10):1169-78
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 12411497Nielsen AL, Sanchez C, Ichinose H, Cervino M, Lerouge T, Chambon P, Losson R. Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha.EMBO J 2002 Nov 1;21(21):5797-5806 View 344 categorized literature findings and their references in IPA
Molecular Functions
chromatin binding, identical protein binding, protein binding, transcription repressor activity
Protein Domains
chromatin binding, chromodomain, chromoshadow domain, protein binding, protein self binding
Subcellular Locations
centromeres, chromatin, cytoplasm, mitotic spindle, nuclear foci, nuclear fraction, nuclear rim, nucleoli, nucleoplasm, nucleus, pericentric heterochromatin, XY bodies
