FES - feline sarcoma oncogene
Entrez Gene Name: feline sarcoma oncogene
Entrez GeneID: Human(2242)
, Mouse(14159), Rat(361597)
, Mouse(14159), Rat(361597) Synonyms: AI586313, BB137047, C-FES, FES, Fes predicted, FPS, RGD1564385, V-FPS
Gene Summary
- Human (2242): This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell proliferation, multicellular organismal development, peptidyl-tyrosine phosphorylation, protein amino acid phosphorylation
Literature References
- 12093729Mitsui N, Inatome R, Takahashi S, Goshima Y, Yamamura H, Yanagi S. Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.EMBO J 2002 07 1;21(13):3274-85
- 17595334Voisset E, Lopez S, Dubreuil P, De Sepulveda P. The tyrosine kinase FES is an essential effector of KITD816V proliferation signal.Blood 2007 Oct 01;110(7):2593-9
- 11021537Hackenmiller R, Kim J, Feldman RA, Simon MC. Abnormal Stat activation, hematopoietic homeostasis, and innate immunity in c-fes-/- mice.Immunity 2000 Sep 1;13(3):397-407 View 366 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity
Protein Domains
FCH domain, kinase, kinase domain, Protein kinase, protein-tyrosine kinase, SH2 domain
Subcellular Locations
cytoplasm, growth cone, microtubule organizing centers, microtubules, neurites, neuronal varicosities, nucleus, perinuclear region
