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SNAP25 - synaptosomal-associated protein, 25kDa
Entrez Gene Name: synaptosomal-associated protein, 25kDa
Entrez GeneID: Human(6616)
, Mouse(20614), Rat(25012)
, Mouse(20614), Rat(25012) Synonyms: bA416N4.2, BDR, dJ1068F16.2, FLJ23079, MGC105414, RIC-4, SEC9, SNAP, SNAP25, Snap25a, sp
Gene Summary
- Human (6616): Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq]
- Rat (25012): forms a complex with synaptobrevin 2 and syntaxin 1A that initiates membrane fusion during neuronal exocytosis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
axonogenesis, calcium ion-dependent exocytosis of neurotransmitter, endosome transport, energy reserve metabolic process, exocytosis, glutamate secretion, growth hormone secretion, long-term memory, neurotransmitter secretion, neurotransmitter uptake, positive regulation of hormone secretion, positive regulation of insulin secretion, potassium ion transmembrane transport, regulation of insulin secretion, regulation of ion transmembrane transport, regulation of synaptogenesis, sleep, synaptic transmission, synaptic vesicle docking involved in exocytosis
Cellular Components
actin cytoskeleton, axon, axonal growth cone, cell junction, cytoplasm, endosome, filopodium, growth cone, intracellular organelle, lamellipodium, membrane, membrane raft, neuron projection, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, SNARE complex, soluble fraction, synapse, synaptobrevin 2-SNAP-25-syntaxin-1a complex, synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex, synaptosome, trans-Golgi network, voltage-gated potassium channel complex
Literature References
- 12526776Shin OH, Rhee JS, Tang J, Sugita S, Rosenmund C, Sudhof TC. Sr(2+) Binding to the Ca(2+) Binding Site of the Synaptotagmin 1 C(2)B Domain Triggers Fast Exocytosis without Stimulating SNARE Interactions.Neuron 2003 Jan 9;37(1):99-108
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 17609207Chen S, Barbieri JT. Multiple Pocket Recognition of SNAP25 by Botulinum Neurotoxin Serotype E.J Biol Chem 2007 Aug 31;282(35):25540-7
Molecular Functions
myosin binding, protein binding, protein domain specific binding, protein N-terminus binding, SNAP receptor activity, SNARE binding, syntaxin-1 binding, voltage-gated potassium channel activity
Protein Domains
coiled-coil domain, cytoplasmic domain, helical domain, myosin binding, palmitoylation site, protein binding, protein domain specific binding, protein N-terminus binding, SNAP receptor, SNAP-25 family, SNARE binding, syntaxin-1 binding, t_SNARE, transmembrane domain, transporter, voltage-gated potassium channel
Subcellular Locations
actin cytoskeleton, apical membrane, axon component, axons, cell surface, cellular membrane, cellular protrusions, clathrin-coated vesicles, Cytoplasm, cytosol, dense core granules, detergent-soluble fraction, detergent-soluble membrane fractions, early endosomal fractions, endosomes, endosomes and endoplasmic reticulum fractions, filopodia, granule membrane, granules, growth cone, intracellular membrane fractions, intracellular membranes, intracellular space, lamellipodia, membrane fraction, membrane rafts, microsome, mossy fibers, motor endplates, myelin enriched fraction, neurites, perikaryon, perinuclear region, Plasma Membrane, presynaptic membrane, presynaptic terminals, soluble fraction, synapse, synaptic clefts, synaptic plasma membrane fractions, synaptic vesicle fractions, synaptic vesicles, synaptosomal fractions, synaptosomes, trans Golgi network