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TUBA8 - tubulin, alpha 8
Entrez Gene Name: tubulin, alpha 8
Synonyms: LOC682022, TUBA8, TUBAL2

Gene Summary

No Data Available

Cell Regulation

Regulates:
  • Kinesin
  • Dynein
  • GTP
View all 15 in IPA
Regulated by:
  • paclitaxel
  • HDAC6
  • MAPT
View all 136 in IPA
Binds:
  • Beta tubulin
  • MYC
  • CCT7
View all 92 in IPA
Role in cell:
  • binding
  • morphology
  • assembly
View all 8 in IPA
Disease:
  • tumor
  • non-small-cell lung carcinoma
  • breast cancer
View all 93 in IPA

Biological Process

microtubule cytoskeleton organization, microtubule-based movement, microtubule-based process, protein polymerization

Cellular Components

microtubule, protein complex

Literature References

  • 12486001Chen D, Wang M, Zhou S, Zhou Q. HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.EMBO J 2002 Dec 16;21(24):6801-6810
  • 17656359Xuan C, Qiao W, Gao J, Liu M, Zhang X, Cao Y, Chen Q, Geng Y, Zhou J. Regulation of microtubule assembly and stability by the transactivator of transcription protein of jembrana disease virus.J Biol Chem 2007 Sep 28;282(39):28800-6
  • 17392473Dompierre JP, Godin JD, Charrin BC, Cordelières FP, King SJ, Humbert S, Saudou F. Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.J Neurosci 2007 Mar 28;27(13):3571-83
  • View 1256 categorized literature findings and their references in IPA

Molecular Functions

GTP binding, GTPase activity, nucleotide binding, structural constituent of cytoskeleton, structural molecule activity

Protein Domains

GTPase domain, structural constituent of cytoskeleton

Subcellular Locations

No Data Available