KISS1 - KiSS-1 metastasis-suppressor
Entrez Gene Name: KiSS-1 metastasis-suppressor
Entrez GeneID: Human(3814)
, Mouse(280287), Rat(289023)
, Mouse(280287), Rat(289023) Synonyms: Eseptin, KISS1, Kisspeptin-1, metastatin, METASTIN, MGC39258
Gene Summary
- Human (3814): This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq]
- Rat (289023): ligand for the G-protein-coupled receptor GPR54; may be involved in autonomic and sensory neural signaling [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cytoskeleton organization, elevation of cytosolic calcium ion concentration, elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating), G-protein coupled receptor protein signaling pathway, generation of ovulation cycle rhythm, negative regulation of cell migration, negative regulation of cell proliferation, positive regulation of growth hormone secretion, positive regulation of luteinizing hormone secretion, positive regulation of MAPKKK cascade, positive regulation of stress-activated MAPK cascade, positive regulation of synaptic transmission
Cellular Components
apical plasma membrane, cell soma, cytoplasm, extracellular region, extracellular space, neuron projection
Literature References
- 17595229Lapatto R, Pallais JC, Zhang D, Chan YM, Mahan A, Cerrato F, Le WW, Hoffman GE, Seminara SB. Kiss1 / mice exhibit more variable hypogonadism than gpr54 / mice.Endocrinology 2007 Oct 01;148(10):4927-36
- 17656465Li D, Mitchell D, Luo J, Yi Z, Cho SG, Guo J, Li X, Ning G, Wu X, Liu M. Estrogen Regulates KiSS1 Gene Expression through Estrogen Receptor {alpha} and SP Protein Complexes.Endocrinology 2007 Oct 01;148(10):4821-8
- 17563351d'Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, Zahn D, Franceschini I, Caraty A, Carlton MB, Aparicio SA, Colledge WH. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene.Proc Natl Acad Sci U S A 2007 Jun 19;104(25):10714-9
Molecular Functions
G-protein-coupled receptor binding, kisspeptin receptor binding, protein binding
