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REN - renin
Entrez Gene Name: renin
Entrez GeneID: Human(5972)
, Mouse(19701), Rat(24715)
, Mouse(19701), Rat(24715) Synonyms: D19352, FLJ10761, HNFJ2, RATRENAA, REN, Ren-A, REN1, Ren1c, Ren1d, RENAA, RENIN, Rn-1, Rnr
Gene Summary
- Human (5972): Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
- Rat (24715): catalyzes the cleavage of a Leu-Xaa bond in angiotensinogen to generate angiotensin [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiotensin maturation, cell maturation, drinking behavior, establishment of blood-nerve barrier, hormone-mediated signaling pathway, kidney development, male gonad development, mesonephros development, metabolic process, proteolysis, regulation of blood pressure, regulation of blood volume by renin-angiotensin, regulation of MAPKKK cascade, renin-angiotensin regulation of aldosterone production, response to cAMP, response to cGMP, response to drug, response to organic substance, response to stress
Cellular Components
cytoplasmic part, extracellular region, extracellular space, intracellular, membrane, soluble fraction
Literature References
- 19564544Krop M, van Veghel R, Garrelds IM, de Bruin RJ, van Gool JM, van den Meiracker AH, Thio M, van Daele PL, Danser AH. Cardiac Renin levels are not influenced by the amount of resident mast cells.Hypertension 2009 Aug 01;54(2):315-21
- 17846348Markus MA, Goy C, Adams DJ, Lovicu FJ, Morris BJ. Renin enhancer is crucial for full response in Renin expression to an in vivo stimulus.Hypertension 2007 Nov 01;50(5):933-8
- 17785633Todorov VT, Desch M, Schmitt-Nilson N, Todorova A, Kurtz A. Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression.Hypertension 2007 Nov 01;50(5):939-44
Molecular Functions
aspartic-type endopeptidase activity, endopeptidase activity, hydrolase activity, insulin-like growth factor receptor binding, peptidase activity, receptor binding
Protein Domains
A1 Propeptide, aspartic endopeptidase, Cellular and retroviral pepsin-like aspartate proteases, endopeptidase, Eukaryotic aspartyl protease, handle region, insulin-like growth factor receptor binding, peptidase, receptor binding, renin
Subcellular Locations
cellular membrane, crinophagic vacuole, Cytoplasm, cytoplasmic aggregates, Extracellular Space, granules, immature secretory granules, intracellular space, mature secretory granules, nerve ending, plasma, secretory granules, soluble fraction, vesicle membrane, vesicles