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CREB1 - cAMP responsive element binding protein 1
Entrez Gene Name: cAMP responsive element binding protein 1
Entrez GeneID: Human(1385)
, Mouse(12912), Rat(81646)
, Mouse(12912), Rat(81646) Synonyms: 2310001E10Rik, 3526402H21RIK, AV083133, CAMP RESPONSE ELEMENT BINDING PROTEIN 1, Cbp, CREB, CREB1, MGC9284, X2BP
Gene Summary
- Human (1385): This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]
- Rat (81646): binds the cAMP response element in many gene promoters and regulates transcription [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of phospholipase C activity, axon guidance, axonogenesis, cellular response to growth factor stimulus, innate immune response, interspecies interaction between organisms, lactation, mammary gland development, MyD88-dependent toll-like receptor signaling pathway, MyD88-independent toll-like receptor signaling pathway, nerve growth factor receptor signaling pathway, phosphatidylinositol-mediated signaling, pituitary gland development, positive regulation of hormone secretion, positive regulation of multicellular organism growth, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transforming growth factor-beta3 production, protein phosphorylation, regulation of apoptosis, regulation of cell size, regulation of circadian rhythm, regulation of transcription, DNA-dependent, response to drug, response to organic substance, signal transduction, stress-activated MAPK cascade, synaptic transmission, Toll signaling pathway, toll-like receptor 1 signaling pathway, toll-like receptor 2 signaling pathway, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, toll-like receptor signaling pathway, transcription from RNA polymerase II promoter, transcription, DNA-dependent, transforming growth factor beta receptor signaling pathway
Cellular Components
chromatin, mitochondrion, nuclear chromatin, nucleolus, nucleoplasm, nucleus, transcription factor complex
Literature References
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 12805224Mendez-Pertuz M, Sanchez-Pacheco A, Aranda A. The thyroid hormone receptor antagonizes CREB-mediated transcription.EMBO J 2003 Jun 16;22(12):3102-12
- 11988169Lonze BE, Riccio A, Cohen S, Ginty DD. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB.Neuron 2002 Apr 25;34(3):371-85
Molecular Functions
DNA binding, double-stranded DNA binding, protein binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, sequence-specific enhancer binding RNA polymerase II transcription factor activity, transcription cofactor activity, transcription factor binding
- cAMP-mediated signaling
- FGF Signaling
- Neuroprotective Role of THOP1 in Alzheimer's Disease
- P2Y Purigenic Receptor Signaling Pathway
- Synaptic Long Term Potentiation
- Cardiac Hypertrophy Signaling
- B Cell Receptor Signaling
- Huntington's Disease Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Relaxin Signaling
- G-Protein Coupled Receptor Signaling
- ERK/MAPK Signaling
- Hypoxia Signaling in the Cardiovascular System
- CREB Signaling in Neurons
- Protein Kinase A Signaling
- BMP signaling pathway
- Calcium Signaling
- Glucocorticoid Receptor Signaling
- Melanocyte Development and Pigmentation Signaling
- ATM Signaling
- Circadian Rhythm Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- ERK5 Signaling
- Thrombin Signaling
- Phospholipase C Signaling
- Dendritic Cell Maturation
- Corticotropin Releasing Hormone Signaling
- GNRH Signaling
- Neurotrophin/TRK Signaling
- Ephrin Receptor Signaling
- ILK Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- p38 MAPK Signaling
- PI3K Signaling in B Lymphocytes
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Estrogen-Dependent Breast Cancer Signaling
- LPS-stimulated MAPK Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Prostate Cancer Signaling
Protein Domains
activation domain, basic domain, bZIP transcription factor, dimerization domain, DNA binding, DNA binding domain, double-stranded DNA binding, glutamine-rich domain, hydrophobic domain, kinase interacting domain, leucine zipper domain, P-box, phosphorylation site, Pka phosphorylation site, protein binding, serine threonine rich domain, transcription activation domain, transcription cofactor, transcription factor, transcription factor binding, transcription factor, DNA binding, transcription regulator
Subcellular Locations
chromatin, Cytoplasm, cytoplasmic fraction, cytosol, mitochondria, nuclear chromatin, nuclear fraction, nucleoplasm, Nucleus