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SLC10A1 - solute carrier family 10 (sodium/bile acid cotransporter family), member 1

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Entrez Gene Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Entrez GeneID: Human(6554), Mouse(20493), Rat(24777)
Synonyms: NTCP, Ntcp1, SBACT, SLC10A1, Sodium dependent taurocholate cotransporting polypeptide, sodium/bile Acid Cotransporter, Sodium/Taurocholate Cotransporting Polypeptide1

Gene Summary

  • Human (6554): Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2; MIM 601295), and the other being found in the basolateral membranes of hepatocytes (SLC10A1).[supplied by OMIM]
  • Rat (24777): mediates sodium dependent bile acid transport [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • bile salt
  • taurocholic acid
  • bile salt conjugates
View all 17 in IPA
Regulated by:
  • lipopolysaccharide
  • NR1H4
  • RAR ligand-RARα-Retinoic acid-RXRα
View all 63 in IPA
Binds:
  • HNF1A
  • RXRA
  • RARA
View all 38 in IPA
Role in cell:
  • transport in
View all 2 in IPA
Disease:
  • cholestasis
  • liver cancer
  • cholestatic hepatitis
View all 12 in IPA

Biological Process

bile acid and bile salt transport, bile acid metabolic process, ion transport, organic anion transport, sodium ion export, sodium ion transport, transmembrane transport, transport

Cellular Components

basolateral plasma membrane, integral to membrane, integral to plasma membrane, membrane, membrane fraction, plasma membrane

Literature References

  • 19017654Rust C, Wild N, Bernt C, Vennegeerts T, Wimmer R, Beuers U. Bile Acid-induced Apoptosis in Hepatocytes Is Caspase-6-dependent.J Biol Chem 2009 Jan 30;284(5):2908-16
  • 17006912Pauli-Magnus C, Meier PJ. Hepatobiliary transporters and drug-induced cholestasis.Hepatology 2006 Oct 01;44(4):778-87
  • 16720753McRae MP, Lowe CM, Tian X, Bourdet DL, Ho RH, Leake BF, Kim RB, Brouwer KL, Kashuba AD. Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile Acid transport in human and rat hepatocytes.J Pharmacol Exp Ther 2006 Sep 01;318(3):1068-75
View 527 categorized literature findings and their references in IPA

Molecular Functions

bile acid transmembrane transporter activity, bile acid:sodium symporter activity, symporter activity

Pathways

Protein Domains

bile acid transporter, bile acid:sodium symporter, Membrane transport protein, transporter

Subcellular Locations

basolateral cell surfaces, basolateral membrane, cellular membrane, intracellular space, membrane fraction, Plasma Membrane, sinusoidal membrane

IPA Extras