-
Product Directory
Custom Product
-
Services Offered
Custom Capabilities
-
CYB5A - cytochrome b5 type A (microsomal)
Canonical
Pathway
Entrez Gene Name: cytochrome b5 type A (microsomal)
Entrez GeneID: Human(1528)
, Mouse(109672), Rat(64001)
, Mouse(109672), Rat(64001) Synonyms: 0610009N12Rik, B5, CB5, CYB5, CYB5A, Cytb5, CYTOCHROME B5, MCB5, MGC108694, MGC128769
Gene Summary
- Human (1528): The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- Rat (64001): a heme protein that may act as an electron transporter [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
electron transport chain, fatty acid metabolic process, response to cadmium ion, transport, vitamin metabolic process, water-soluble vitamin metabolic process
Cellular Components
cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome, mitochondrial outer membrane, mitochondrion, soluble fraction
Literature References
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 15155908Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA. Molecular diversity of astrocytes with implications for neurological disorders.Proc Natl Acad Sci U S A 2004 Jun 01;101(22):8384-9
- 12477729Thomenius MJ, Wang NS, Reineks EZ, Wang Z, Distelhorst CW. Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3 only proteins.J Biol Chem 2003 02 21;278(8):6243-50
Molecular Functions
aldo-keto reductase (NADP) activity, cytochrome-c oxidase activity, electron carrier activity, enzyme binding, heme binding, metal ion binding, stearoyl-CoA 9-desaturase activity
Protein Domains
aldo-keto reductase, Cytochrome b5-like Heme/Steroid binding domain, cytochrome-c oxidase, electron carrier, enzyme, enzyme binding, ER targeting sequence, stearoyl-CoA 9-desaturase, transmembrane domain
Subcellular Locations
cellular membrane, Cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, Golgi membranes, microsomal membrane, microsome, mitochondria, mitochondrial outer membrane, peroxisomes, pH resistant lipid raft fraction, soluble fraction, vesicles