LDHB - lactate dehydrogenase B
Entrez Gene Name: lactate dehydrogenase B
Entrez GeneID: Human(3945)
, Mouse(16832), Rat(24534)
, Mouse(16832), Rat(24534) Synonyms: -lactate dehydrogenase h-chain, AI790582, H-Ldh, L-lactate dehydrogenase B chain, LDH heart subunit, LDH-H, LDH2, LDHB, TRG-5
Gene Summary
- Rat (24534): member of the lactate dehydrogenase enzyme family, which catalyzes the conversion of lactate to pyruvate [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
| Disease:
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Biological Process
anaerobic glycolysis, carbohydrate metabolic process, cellular carbohydrate metabolic process, glycolysis, lactate metabolic process, NAD metabolic process, oxidation reduction
Literature References
- 12145195Crawford RM, Budas GR, Jovanović S, Ranki HJ, Wilson TJ, Davies AM, Jovanović A. M-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemia.EMBO J 2002 Aug 1;21(15):3936-48
- 16914559Yonezawa A, Masuda S, Yokoo S, Katsura T, Inui K. Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).J Pharmacol Exp Ther 2006 Nov 01;319(2):879-86
- 15908226Wang W, Duan W, Igarashi S, Morita H, Nakamura M, Ross CA. Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model.Neurobiol Dis 2005 Nov 01;20(2):500-8 View 315 categorized literature findings and their references in IPA
Molecular Functions
binding, catalytic activity, identical protein binding, L-lactate dehydrogenase activity, lactate dehydrogenase activity, NAD or NADH binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding
Protein Domains
enzyme, L-lactate dehydrogenase, lactate dehydrogenase, NAD binding domain, protein binding, protein self binding
Subcellular Locations
cytoplasm, cytosol, detergent resistant lipid raft fraction, exosomes, myelin enriched fraction
