NOD2 - nucleotide-binding oligomerization domain containing 2
Entrez Gene Name: nucleotide-binding oligomerization domain containing 2
Entrez GeneID: Human(64127)
, Mouse(257632), Rat(291912)
, Mouse(257632), Rat(291912) Synonyms: ACUG, BLAU, CARD15, CD, CLR16.3, F830032C23Rik, IBD1, NLRC2, NOD2, NOD2B, PSORAS1
Gene Summary
- Human (64127): This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulated by:
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Biological Process
activation of immune response, cytokine production during immune response, defense response to bacterium, defense response to Gram-positive bacterium, detection of bacterium, detection of muramyl dipeptide, immunoglobulin production during immune response, inflammatory response, innate immune response in mucosa, intracellular signaling cascade, microglial cell activation during immune response, negative regulation of interferon-gamma production, negative regulation of interleukin-12 production, negative regulation of interleukin-18 production, negative regulation of NF-kappaB transcription factor activity, negative regulation of toll-like receptor 2 signaling pathway, pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity, positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria, positive regulation of cell proliferation, positive regulation of dendritic cell cytokine production, positive regulation of ERK1 and ERK2 cascade, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of innate immune response, positive regulation of interleukin-1 beta secretion, positive regulation of interleukin-12 production, positive regulation of interleukin-17 production, positive regulation of interleukin-6 production, positive regulation of JNK cascade, positive regulation of MAPKKK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of stress-activated MAPK cascade, positive regulation of tumor necrosis factor production, protein oligomerization, regulation of apoptosis, response to exogenous dsRNA, response to lipopolysaccharide, response to muramyl dipeptide, response to peptidoglycan
Cellular Components
cell surface, cytoplasm, cytosol, intracellular, plasma membrane, signalosome, vesicle
Literature References
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 17804789Raelson JV, Little RD, Ruether A, Fournier H, Paquin B, Van Eerdewegh P, Bradley WE, Croteau P, Nguyen-Huu Q, Segal J, Debrus S, Allard R, Rosenstiel P, Franke A, Jacobs G, Nikolaus S, Vidal JM, Szego P, Laplante N, Clark HF, Paulussen RJ, Hooper JW, Keith TP, Belouchi A, Schreiber S. Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.Proc Natl Acad Sci U S A 2007 09 11;104(37):14747-52
- 17355968Lécine P, Esmiol S, Métais JY, Nicoletti C, Nourry C, McDonald C, Nunez G, Hugot JP, Borg JP, Ollendorff V. The NOD2-RICK complex signals from the plasma membrane.J Biol Chem 2007 May 18;282(20):15197-207
Molecular Functions
ATP binding, CARD domain binding, enzyme binding, muramyl dipeptide binding, nucleotide binding, protein binding, protein kinase binding
Protein Domains
Card domain, CARD domain binding, enzyme binding, leucine-rich repeat, nucleotide-binding domain, protein binding, protein kinase binding
Subcellular Locations
basolateral membrane, cytoplasm, granules, intercellular junctions, perinuclear region, plasma membrane
