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NR1I3 - nuclear receptor subfamily 1, group I, member 3
Entrez Gene Name: nuclear receptor subfamily 1, group I, member 3
Entrez GeneID: Human(9970)
, Mouse(12355), Rat(65035)
, Mouse(12355), Rat(65035) Synonyms: AA209988, AI551208, CAR, CAR-BETA, CAR1, CAR2, Care2, Constitutive androstane receptor, ESTM32, MB67, MGC107281, MGC108525, MGC150433, MGC97144, MGC97209, NR1I3
Gene Summary
- Human (9970): This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Rat (65035): regulatory factor that leads to the sexual dimorphic induction of CYP2B1 gene [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulated by:
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Biological Process
androgen receptor signaling pathway, gene expression, intracellular receptor mediated signaling pathway, negative regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor, regulation of transcription, DNA-dependent, signal transduction, steroid hormone mediated signaling pathway, transcription, DNA-dependent
Literature References
- 12376703Zhang J, Huang W, Chua SS, Wei P, Moore DD. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.Science 2002 Oct 11;298(5592):422-4
- 20622021Benet M, Lahoz A, Guzmán C, Castell JV, Jover R. CCAAT/Enhancer-binding Protein {alpha} (C/EBP{alpha}) and Hepatocyte Nuclear Factor 4{alpha} (HNF4{alpha}) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene: APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL.J Biol Chem 2010 Sep 10;285(37):28457-71
- 18723825Knight TR, Choudhuri S, Klaassen CD. Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers.Toxicol Sci 2008 Dec 01;106(2):329-38
Molecular Functions
androgen receptor activity, DNA binding, ligand-dependent nuclear receptor activity, metal ion binding, protein binding, receptor activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, steroid hormone receptor activity, thyroid hormone receptor activity, transcription coactivator activity, zinc ion binding
Protein Domains
AF-2 transcription activation domain, alpha helix, androgen receptor, dimerization domain, DNA binding, DNA binding domain, DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers, ligand-binding domain, ligand-dependent nuclear receptor, nuclear receptor ligand binding domain, protein binding, transcription co-activator, xenobiotic response sequence