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ACTG1 - actin, gamma 1

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Gene
Details

Interaction
Network

Canonical
Pathway

Literature

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Disease

Compound

Expression

Regulation

SNP

Entrez Gene Name: actin, gamma 1
Entrez GeneID: Human(71), Mouse(11465), Rat(287876)
Synonyms: ACT, ACTG, ACTG1, Actin gamma, ACTL, AL023024, beta-actin, Chi-actin, DFNA20, DFNA26, E51, G-actin, GAMMA ACTIN, MGC117491, MGC28612

Gene Summary

  • Human (71): Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • Actin
  • SLC2A4
  • F Actin
View all 80 in IPA
Regulated by:
  • WAS
  • Tcr
  • F2
View all 680 in IPA
Binds:
  • VCL
  • Myosin
  • EZR
View all 260 in IPA
Role in cell:
  • morphology
  • motility
  • endocytosis by
View all 73 in IPA
Disease:
  • cystic fibrosis
  • childhood acute lymphoblastic leukemia
  • acute kidney injury
View all 10 in IPA

Biological Process

adherens junction organization, axon guidance, blood coagulation, cell junction assembly, cell-cell junction organization, cellular component movement, response to calcium ion, sarcomere organization

Cellular Components

actin cytoskeleton, axon, costamere, cytoplasm, cytoskeleton, cytosol, filamentous actin, myofibril

Literature References

  • 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
  • 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 10 20;437(7062):1173-8
  • 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
View 2931 categorized literature findings and their references in IPA

Molecular Functions

ATP binding, identical protein binding, nucleotide binding, protein binding, protein kinase binding, structural constituent of cytoskeleton

Pathways

Protein Domains

ACTIN, Actin, identical protein binding, protein binding, structural constituent of cytoskeleton

Subcellular Locations

actin cytoskeleton, actin filaments, axons, cell periphery, costameres, Cytoplasm, cytoskeleton, cytosol, filopodia, Golgi membranes, growth cone, microsome, myelin enriched fraction, myofibrils, neurites, nucleoli, Nucleus, perikaryon, phagosomes, sarcolemma, Z line

IPA Extras