ACTG1 - actin, gamma 1
Entrez Gene Name: actin, gamma 1
Entrez GeneID: Human(71)
, Mouse(11465), Rat(287876)
, Mouse(11465), Rat(287876) Synonyms: ACT, ACTG, ACTG1, Actin gamma, ACTL, AL023024, beta-actin, Chi-actin, DFNA20, DFNA26, E51, GAMMA ACTIN, MGC117491, MGC28612
Gene Summary
- Human (71): Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell motion, response to calcium ion, sarcomere organization, sensory perception of sound
Literature References
- 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
- 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 Oct 20;437(7062):1173-8
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
Molecular Functions
ATP binding, identical protein binding, nucleotide binding, protein binding, structural constituent of cytoskeleton
- VEGF Signaling
- Tight Junction Signaling
- Mechanisms of Viral Exit from Host Cells
- Cellular Effects of Sildenafil (Viagra)
- ILK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- FAK Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Integrin Signaling
- Actin Cytoskeleton Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Caveolar-mediated Endocytosis Signaling
- NRF2-mediated Oxidative Stress Response
- Agrin Interactions at Neuromuscular Junction
- Clathrin-mediated Endocytosis Signaling
- Leukocyte Extravasation Signaling
- Virus Entry via Endocytic Pathways
Subcellular Locations
axons, cell body, cell periphery, cytoplasm, filopodia, Golgi membranes, growth cone, microsome, myelin enriched fraction, neurites, nucleoli, nucleus, phagosomes, sarcolemma, Z line
