INA - internexin neuronal intermediate filament protein, alpha
Entrez Gene Name: internexin neuronal intermediate filament protein, alpha
Entrez GeneID: Human(9118)
, Mouse(226180), Rat(24503)
, Mouse(226180), Rat(24503) Synonyms: ALPHA INTERNEXIN, Alpha-Inx, AV028420, FLJ18662, FLJ57501, INA, Inexa, Intlaa, MGC12702, MGC25352, NEF5, NEUROFILAMENT-66, NF-66, TXBP-1
Gene Summary
- Human (9118): Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq]
- Rat (24503): may play a role in neurogenesis; may be involved in neuronal regeneration in response to injury [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell differentiation, intermediate filament cytoskeleton organization, multicellular organismal development, nervous system development, neurofilament cytoskeleton organization, tissue regeneration
Literature References
- 16858073Laterza OF, Modur VR, Crimmins DL, Olander JV, Landt Y, Lee JM, Ladenson JH. Identification of novel brain biomarkers.Clin Chem 2006 Sep 01;52(9):1713-21
- 9435256Reddy TR, Li X, Jones Y, Ellisman MH, Ching GY, Liem RK, Wong-Staal F. Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein.Proc Natl Acad Sci U S A 1998 Jan 20;95(2):702-7
- 11089575Wong NK, He BP, Strong MJ. Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic amyotrophic lateral sclerosis (ALS).J Neuropathol Exp Neurol 2000 Nov 01;59(11):972-82 View 131 categorized literature findings and their references in IPA
Subcellular Locations
cytoplasm, filamentous network, myelin enriched fraction, neurofilaments, postsynaptic density (PSD) fractions
