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ABCG2 - ATP-binding cassette, sub-family G (WHITE), member 2
Canonical
Pathway
Entrez Gene Name: ATP-binding cassette, sub-family G (WHITE), member 2
Entrez GeneID: Human(9429)
, Mouse(26357), Rat(312382)
, Mouse(26357), Rat(312382) Synonyms: ABC1, ABC15, ABCG2, ABCP, AI428558, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, MGC102821, MRX, MXR, MXR1
Gene Summary
- Human (9429): The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq]
- Mouse (26357): The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
ATP catabolic process, cellular iron ion homeostasis, drug export, drug transmembrane transport, drug transport, embryonic process involved in female pregnancy, heme transport, metabolic process, response to drug, response to folic acid, response to glucocorticoid stimulus, response to iron ion, transmembrane transport, transport, urate metabolic process
Cellular Components
apical plasma membrane, integral to membrane, membrane, membrane fraction, nucleus, plasma membrane
Literature References
- 16337012Breedveld P, Beijnen JH, Schellens JH. Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs.Trends Pharmacol Sci 2006 Jan 01;27(1):17-24
- 12045106Borst P, Elferink RO. Mammalian ABC transporters in health and disease.Annu Rev Biochem 2002;71:537-92
- 19333723Mosaffa F, Lage H, Afshari JT, Behravan J. Interleukin-1 beta and tumor necrosis factor-alpha increase ABCG2 expression in MCF-7 breast carcinoma cell line and its mitoxantrone-resistant derivative, MCF-7/MX.Inflamm Res 2009 Oct 01;58(10):669-76
Molecular Functions
ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, drug transmembrane transporter activity, heme transporter activity, nucleoside-triphosphatase activity, nucleotide binding, protein binding, protein dimerization activity, protein homodimerization activity, transporter activity, xenobiotic-transporting ATPase activity
Protein Domains
ABC exporter ATP-binding subunit, DevA family, ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system, ABC-2 type transporter, ATPase activity, coupled to transmembrane movement of substances, catalytic domain, cell division ATP-binding protein FtsE, cobalt transport protein ATP-binding subunit, drug transporter, ectoine/hydroxyectoine ABC transporter, ATP-binding protein, FeS assembly ATPase SufC, gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit, heme ABC exporter, ATP-binding protein CcmA, heme transporter, lipoprotein releasing system, ATP-binding protein, nickel import ATP-binding protein NikD, nickel import ATP-binding protein NikE, nitrate transport ATP-binding subunits C and D, nucleotide-binding domain, P-loop containing Nucleoside Triphosphate Hydrolases, phosphate ABC transporter, ATP-binding protein, phosphonate ABC transporter, ATP-binding protein, phosphonate C-P lyase system protein PhnL, phosphorylation site, proposed F420-0 ABC transporter, ATP-binding protein, protein binding, protein dimerization, protein homodimerization, putative bacteriocin export ABC transporter, lactococcin 972 group, sulfate ABC transporter, ATP-binding protein, The Eye Pigment Precursor Transporter (EPP) Family protein, thiamine ABC transporter, ATP-binding protein, transmembrane domain, transporter, Type II (General) Secretory Pathway (IISP) Family protein, urea ABC transporter, ATP-binding protein UrtD, xenobiotic-transporting ATPase
Subcellular Locations
apical membrane, cell surface, cellular membrane, exosomes, Golgi stacks, intracellular space, lysosome, membrane fraction, Nucleus, Plasma Membrane, vesicles