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ACTG2 - actin, gamma 2, smooth muscle, enteric
Entrez Gene Name: actin, gamma 2, smooth muscle, enteric
Entrez GeneID: Human(72)
, Mouse(11475), Rat(25365)
, Mouse(11475), Rat(25365) Synonyms: 0610041G09Rik, a-SMA, ACT, Act-4, Acta2, ACTA3, ACTE, ACTG2, ACTGE, actin gamma, ACTL3, ACTSG, Actvs, Alpha smooth muscle actin, alpha-SMA, ENTERIC SMOOTH MUSCLE GAMMA ACTIN, MGC105507, SM Alpha Actin, SMalphaA, SMGA, SMOOTH MUSCLE GAMMA ACTIN, Vascular Smooth Muscle Alpha-Actin
Gene Summary
- Human (72): Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]
- Rat (25365): may play a role in smooth muscle function [RGD, Feb 2006]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
muscle contraction, regulation of blood pressure, vascular smooth muscle contraction
Cellular Components
actin cytoskeleton, cell periphery, cytoplasm, cytoskeleton, cytosol, smooth muscle contractile fiber
Literature References
- 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 Jan 01;19(1):1-49
- 14592989Stüven T, Hartmann E, Görlich D. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.EMBO J 2003 Nov 03;22(21):5928-40
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Cellular Effects of Sildenafil (Viagra)
- Paxillin Signaling
- MSP-RON Signaling Pathway
- FAK Signaling
- Leukocyte Extravasation Signaling
- Mechanisms of Viral Exit from Host Cells
- Gap Junction Signaling
- Clathrin-mediated Endocytosis Signaling
- Agrin Interactions at Neuromuscular Junction
- Sertoli Cell-Sertoli Cell Junction Signaling
- RhoA Signaling
- Integrin Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Virus Entry via Endocytic Pathways
- ILK Signaling
- Actin Cytoskeleton Signaling
- NRF2-mediated Oxidative Stress Response
- Caveolar-mediated Endocytosis Signaling
- Signaling by Rho Family GTPases
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- RhoGDI Signaling
- Regulation of Actin-based Motility by Rho
- VEGF Signaling
- Tight Junction Signaling
Subcellular Locations
actin cytoskeleton, cell surface, Cytoplasm, cytoskeleton, cytosol, myofibrils