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ACTG2 (includes EG:72) - actin, gamma 2, smooth muscle, enteric
Entrez Gene Name: actin, gamma 2, smooth muscle, enteric
Synonyms: 0610041G09Rik, a-SMA, ACT, Act-4, Acta2, ACTA3, ACTE, ACTG2 (includes EG:72), ACTGE, actin gamma, ACTL3, ACTSG, Actvs, Alpha smooth muscle actin, alpha-SMA, ENTERIC SMOOTH MUSCLE GAMMA ACTIN, MGC105507, SM Alpha Actin, SMalphaA, SMGA, SMOOTH MUSCLE GAMMA ACTIN, Vascular Smooth Muscle Alpha-Actin

Gene Summary

  • Human (72): Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues. [provided by RefSeq]
  • Rat (25365): may play a role in smooth muscle function [RGD]

Cell Regulation

Regulates:
  • Actin
  • YOPO
  • GRIA1
View all 88 in IPA
Regulated by:
  • TGFB1
  • WAS
  • F2
View all 718 in IPA
Binds:
  • KEAP1
  • EZR
  • VCL
View all 198 in IPA
Role in cell:
  • formation
  • morphology
  • transport
View all 52 in IPA
Disease:
  • cystic fibrosis
  • myocardial infarction
  • infection
View all 5 in IPA

Biological Process

regulation of blood pressure, vascular smooth muscle contraction

Cellular Components

actin cytoskeleton, cytoplasm, cytoskeleton, smooth muscle contractile fiber

Literature References

  • 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
  • 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
  • 14592989Stuven T, Hartmann E, Gorlich D. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.EMBO J 2003 11 3;22(21):5928-40
  • View 3281 categorized literature findings and their references in IPA

Molecular Functions

ATP binding, nucleotide binding, protein binding

Protein Domains

motor protein, structural constituent of muscle

Subcellular Locations

cell surface, cytoplasm