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NISCH - nischarin

Product
List

Gene
Details

Interaction
Network

Canonical
Pathway

Literature

Clinical Trial

Disease

Compound

Expression

Regulation

SNP

Entrez Gene Name: nischarin
Entrez GeneID: Human(11188), Mouse(64652), Rat(306255)
Synonyms: 1200007D05Rik, 3202002H23Rik, AW494485, FLJ14425, FLJ40413, FLJ90519, I-1, I1 receptor, Imidazoline-1 Receptor, IRAS, KIAA0975, NISCH, Nischarin

Gene Summary

No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • D-glucose
  • norepinephrine
View all 3 in IPA
Regulated by:
  • DMD
  • IFNB1 (includes EG:15977)
  • moxonidine
View all 6 in IPA
Binds:
  • ITGA5
  • MAPK3
  • Irs3
View all 10 in IPA
Role in cell:
  • organization
  • migration
View all 4 in IPA
Disease:
  • No Data Available

Biological Process

actin cytoskeleton organization, apoptosis, cell communication, G-protein coupled receptor protein signaling pathway, glucose metabolic process, negative regulation of cell migration, norepinephrine secretion, Rac protein signal transduction, regulation of blood pressure, regulation of synaptic transmission, GABAergic

Cellular Components

cytoplasm, cytosol, early endosome, endosome, membrane, membrane fraction, plasma membrane, recycling endosome

Literature References

  • 15075383El-Ayoubi R, Menaouar A, Gutkowska J, Mukaddam-Daher S. Imidazoline receptors but not alpha2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment.J Pharmacol Exp Ther 2004 Aug 01;310(2):446-51
  • 11912194Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE. Insulin receptor substrate 4 associates with the protein IRAS.J Biol Chem 2002 May 31;277(22):19439-47
  • 11121431Alahari SK, Lee JW, Juliano RL. Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration.J Cell Biol 2000 Dec 11;151(6):1141-54
View 101 categorized literature findings and their references in IPA

Molecular Functions

G-protein coupled amine receptor activity, integrin binding, phosphatidylinositol binding, receptor activity

Pathways

No Data Available

Protein Domains

acidic domain, amine receptor, integrin binding, Leucine Rich repeats (2 copies), The Phox Homology domain, a phosphoinositide binding module, transmembrane receptor

Subcellular Locations

cytosol, cytosolic fraction, detergent-insoluble membrane fraction, detergent-soluble membrane fractions, membrane fraction, perinuclear region, Plasma Membrane, soluble fraction

IPA Extras

View additional information available in IPA's curated and annotated database: