ACTA1 - actin, alpha 1, skeletal muscle
Entrez Gene Name: actin, alpha 1, skeletal muscle
Entrez GeneID: Human(58)
, Mouse(11459), Rat(29437)
, Mouse(11459), Rat(29437) Synonyms: AA959943, ACTA, Acta-2, ACTA1, Acts, Actsk-1, ALPHA SKELETAL ACTIN, ALPHA1 ACTIN, ASMA, CFTD, CFTD1, CFTDM, Fetal isoform of skeletal alpha-actin, G-actin, MPFD, NEM1, NEM2, NEM3, SKA, SKELETAL ALPHA-ACTIN, SKELETAL MUSCLE ACTIN
Gene Summary
- Human (58): The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq]
- Rat (29437): may act as a structural component of the cytoskeleton; may play a role in muscle function [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell growth, muscle contraction, muscle thin filament assembly, response to extracellular stimulus, response to long exposure to lithium ion, response to mechanical stimulus, response to steroid hormone stimulus, skeletal muscle fiber adaptation, skeletal muscle fiber development
Cellular Components
actin filament, cytoplasm, cytoskeleton, stress fiber, striated muscle thin filament
Literature References
- 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 14592989Stuven T, Hartmann E, Gorlich D. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.EMBO J 2003 11 3;22(21):5928-40 View 3397 categorized literature findings and their references in IPA
Molecular Functions
ADP binding, ATP binding, myosin binding, nucleotide binding, protein binding, structural constituent of cytoskeleton
- Germ Cell-Sertoli Cell Junction Signaling
- FAK Signaling
- Clathrin-mediated Endocytosis Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Calcium Signaling
- Mechanisms of Viral Exit from Host Cells
- Leukocyte Extravasation Signaling
- Integrin Signaling
- Virus Entry via Endocytic Pathways
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Caveolar-mediated Endocytosis Signaling
- VEGF Signaling
- Agrin Interactions at Neuromuscular Junction
- Tight Junction Signaling
- Regulation of Actin-based Motility by Rho
- NRF2-mediated Oxidative Stress Response
- ILK Signaling
- Actin Cytoskeleton Signaling
- Cellular Effects of Sildenafil (Viagra)
Protein Domains
ATP binding, motor protein, myosin binding, protein binding, structural constituent of cytoskeleton
Subcellular Locations
actin cytoskeleton, actin stress fibers, cytoplasm, filopodia, Golgi membranes, microfilaments
