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KDR - kinase insert domain receptor (a type III receptor tyrosine kinase)
Entrez Gene Name: kinase insert domain receptor (a type III receptor tyrosine kinase)
Entrez GeneID: Human(3791)
, Mouse(16542), Rat(25589)
, Mouse(16542), Rat(25589) Synonyms: 6130401C07, CD309, Flk, FLK1, KDR, Kinase Insert Domain, Krd-1, Ly73, MGC93590, sVEGFR-2, VEGFR, VEGFR-2
Gene Summary
- Human (3791): Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq]
- Rat (25589): receptor for vascular endothelial growth factor (VEGF) [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiogenesis, branching morphogenesis of a tube, calcium ion homeostasis, cell differentiation, cell fate commitment, cell maturation, cell migration, elevation of cytosolic calcium ion concentration, endothelial cell differentiation, hemopoiesis, interspecies interaction between organisms, lung alveolus development, lung development, lymph vessel development, male gonad development, multicellular organismal development, neuron projection morphogenesis, neuroprotection, ovarian follicle development, phosphorylation, positive regulation of angiogenesis, positive regulation of calcium-mediated signaling, positive regulation of cell migration, positive regulation of cell proliferation, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of focal adhesion assembly, positive regulation of long-term neuronal synaptic plasticity, positive regulation of mesenchymal cell proliferation, positive regulation of neurogenesis, positive regulation of phosphatidylinositol 3-kinase cascade, positive regulation of positive chemotaxis, positive regulation of TOR signaling cascade, positive regulation of vasodilation, protein autophosphorylation, regulation of cell shape, response to chemical stimulus, response to drug, response to hypoxia, surfactant homeostasis, transmembrane receptor protein tyrosine kinase signaling pathway, vascular endothelial growth factor receptor signaling pathway, vasculogenesis
Cellular Components
cell periphery, cytoplasm, integral to membrane, integral to plasma membrane, membrane, membrane fraction, neuron projection, neuronal cell body, plasma membrane
Literature References
- 11387210Takahashi T, Yamaguchi S, Chida K, Shibuya M. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.EMBO J 2001 Jun 1;20(11):2768-78
- 10747021Binétruy-Tournaire R, Demangel C, Malavaud B, Vassy R, Rouyre S, Kraemer M, Plouët J, Derbin C, Perret G, Mazié JC. Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis.EMBO J 2000 Apr 3;19(7):1525-33
- 9529250Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.Cell 1998 Mar 20;92(6):735-45
Molecular Functions
ATP binding, growth factor binding, Hsp90 protein binding, integrin binding, kinase activity, nucleotide binding, protein binding, receptor activity, receptor signaling protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor receptor activity
Protein Domains
autophosphorylation site, catalytic domain, cytoplasmic domain, cytosolic tail domain, extracellular domain, growth factor binding, Immunoglobulin domain, immunoglobulin domain, Immunoglobulin V-set domain, immunoglobulin-like protein domain, integrin binding, intracellular domain, kinase, kinase domain, ligand-binding domain, membrane-proximal domain, protein binding, Protein kinase (unclassified specificity), Protein Kinases, catalytic domain, protein-tyrosine kinase, receptor signaling protein tyrosine kinase, transmembrane domain, transmembrane receptor protein tyrosine kinase, tyrosine kinase domain, vascular endothelial growth factor receptor
Subcellular Locations
axons, cell surface, cellular membrane, cis Golgi cisternae, Cytoplasm, growth cone, intercellular junctions, membrane fraction, neurites, nodes of Ranvier, Nucleus, perikaryon, perinuclear region, Plasma Membrane, plasma membrane extracellular face