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MAPK14 - mitogen-activated protein kinase 14
Entrez Gene Name: mitogen-activated protein kinase 14
Entrez GeneID: Human(1432)
, Mouse(26416), Rat(81649)
, Mouse(26416), Rat(81649) Synonyms: CRK1, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Hog, MAPK p38, MAPK14, MGC102436, MGC105413, MGC142910, MXI2, P38, P38 KINASE, P38 Map Kinase, p38 MAPK, p38 Mapk alpha, p38 MAPK-α, P38-ALPHA, p38-RK, p38/Hog1, p38/Mpk2, P38/RK, p38a, p38Hog, PRKM14, PRKM15, RK, SAPK2A
Gene Summary
- Human (1432): The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
- Rat (81649): mitogen-activated protein kinase; involved in intracellular signalling, inhibition of apoptosis and gene activation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, angiogenesis, blood coagulation, cell morphogenesis, cell surface receptor linked signaling pathway, cellular component movement, cellular response to ionizing radiation, chemotaxis, chondrocyte differentiation, DNA damage checkpoint, fatty acid oxidation, glucose metabolic process, innate immune response, intracellular protein kinase cascade, lipopolysaccharide-mediated signaling pathway, metabolic process, mRNA metabolic process, muscle cell differentiation, MyD88-dependent toll-like receptor signaling pathway, MyD88-independent toll-like receptor signaling pathway, nerve growth factor receptor signaling pathway, peptidyl-serine phosphorylation, phosphorylation, platelet activation, positive regulation of erythrocyte differentiation, positive regulation of muscle cell differentiation, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription from RNA polymerase II promoter, protein autophosphorylation, protein phosphorylation, Ras protein signal transduction, regulation of sequence-specific DNA binding transcription factor activity, response to glucose stimulus, response to lipopolysaccharide, response to muramyl dipeptide, response to stress, RNA metabolic process, signal transduction, signal transduction in response to DNA damage, skeletal muscle tissue development, stress-activated MAPK cascade, stress-induced premature senescence, striated muscle cell differentiation, Toll signaling pathway, toll-like receptor 1 signaling pathway, toll-like receptor 2 signaling pathway, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, toll-like receptor signaling pathway
Cellular Components
cell, cytoplasm, cytosol, cytosolic part, mitochondrion, nucleoplasm, nucleus, soluble fraction, spindle pole
Literature References
- 17255949Casar B, Sanz-Moreno V, Yazicioglu MN, Rodríguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P. Mxi2 promotes stimulus-independent ERK nuclear translocation.EMBO J 2007 Feb 07;26(3):635-46
- 12065415Wang S, Zhang B, Faller DV. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.EMBO J 2002 Jun 17;21(12):3019-28
- 11861597Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response.Annu Rev Immunol 2002;20:55-72
Molecular Functions
ATP binding, kinase activity, MAP kinase activity, MAP kinase kinase activity, nucleotide binding, protein binding, protein C-terminus binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups
- Factors Promoting Cardiogenesis in Vertebrates
- Role of Tissue Factor in Cancer
- IL-1 Signaling
- IL-12 Signaling and Production in Macrophages
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- LPS-stimulated MAPK Signaling
- IL-17A Signaling in Airway Cells
- IL-22 Signaling
- PPARα/RXRα Activation
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Amyloid Processing
- BMP signaling pathway
- RANK Signaling in Osteoclasts
- HMGB1 Signaling
- Inhibition of Angiogenesis by TSP1
- IL-6 Signaling
- IL-17 Signaling
- Role of NFAT in Cardiac Hypertrophy
- Thrombin Signaling
- CCR5 Signaling in Macrophages
- RAR Activation
- Leukocyte Extravasation Signaling
- IL-15 Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- GNRH Signaling
- Type I Diabetes Mellitus Signaling
- Cdc42 Signaling
- ATM Signaling
- Molecular Mechanisms of Cancer
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- p53 Signaling
- Cardiac Hypertrophy Signaling
- IL-17A Signaling in Fibroblasts
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- CD40 Signaling
- Toll-like Receptor Signaling
- April Mediated Signaling
- Dendritic Cell Maturation
- B Cell Activating Factor Signaling
- NRF2-mediated Oxidative Stress Response
- Corticotropin Releasing Hormone Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Renin-Angiotensin Signaling
- Xenobiotic Metabolism Signaling
- B Cell Receptor Signaling
- IL-10 Signaling
- Endothelin-1 Signaling
- Glucocorticoid Receptor Signaling
- HIF1α Signaling
- Role of IL-17A in Arthritis
- FGF Signaling
- Parkinson's Signaling
- Fc Epsilon RI Signaling
- Regulation of eIF4 and p70S6K Signaling
- AMPK Signaling
- p38 MAPK Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Acute Phase Response Signaling
- TGF-β Signaling
- IL-17A Signaling in Gastric Cells
- Germ Cell-Sertoli Cell Junction Signaling
- CCR3 Signaling in Eosinophils
Protein Domains
activation domain, ATP binding, ATP-binding domain, common docking domain, kinase, kinase domain, MAP kinase, MAP kinase kinase, phosphorylation site, protein binding, protein C-terminus binding, protein kinase, Protein kinase (unclassified specificity), Protein kinase domain, Protein Kinases, catalytic domain, protein serine/threonine kinase, Protein tyrosine kinase, Serine/Threonine protein kinases, catalytic domain, threonine-glycine-tyrosine activation motif, Tyrosine kinase, catalytic domain
Subcellular Locations
C fiber, cell cortex, Cytoplasm, cytosol, cytosolic fraction, focal adhesions, mitochondria, neurites, nuclear fraction, nucleoplasm, Nucleus, perinuclear region, soluble fraction, spindle pole