SMARCA2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Entrez Gene Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Entrez GeneID: Human(6595)
, Mouse(67155), Rat(361745)
, Mouse(67155), Rat(361745) Synonyms: 2610209L14RIK, BAF190, brahma, BRM, FLJ36757, HBRM, hSNF2a, MGC74511, SMARCA2, SNF2, SNF2alpha, SNF2L2, SNF2LA, Sth1p, SWI2
Gene Summary
- Human (6595): The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq]
- Rat (361745): mouse homolog plays a role in regulation of cell proliferation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
chromatin remodeling, establishment or maintenance of chromatin architecture, negative regulation of cell proliferation, negative regulation of specific transcription from RNA polymerase II promoter, nucleosome assembly, positive regulation of specific transcription from RNA polymerase II promoter, regulation of transcription, regulation of transcription from RNA polymerase II promoter
Literature References
- 15696166Harikrishnan KN, Chow MZ, Baker EK, Pal S, Bassal S, Brasacchio D, Wang L, Craig JM, Jones PL, Sif S, El-Osta A. Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.Nat Genet 2005 Mar 01;37(3):254-64
- 12757710Iakova P, Awad SS, Timchenko NA. Aging Reduces Proliferative Capacities of Liver by Switching Pathways of C/EBPalpha Growth Arrest.Cell 2003 May 16;113(4):495-506
- 12065415Wang S, Zhang B, Faller DV. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.EMBO J 2002 Jun 17;21(12):3019-28
Molecular Functions
ATP binding, DNA binding, DNA-dependent ATPase activity, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleotide binding, protein binding, transcription coactivator activity
Protein Domains
bromodomain, carboxy terminal domain, helicase, Helicase domain, LXCXE binding site, N-terminal domain, proline/glutamine rich region, protein binding, retinoblastoma protein binding domain, transcription co-activator, transcription regulator
Subcellular Locations
cellular membrane, chromatin fraction, cytoplasm, interzone, nuclear fraction, nuclear matrix fraction, nucleoplasm, nucleus
